4,9-ジヒドロ-1,3-ジメチル-4-[(4-メチル-1-ピペラジニル)アセチル]ピラゾロ[4,3-b][1,5]ベンゾジアゼピン-10(1H)-オン

4,9-ジヒドロ-1,3-ジメチル-4-[(4-メチル-1-ピペラジニル)アセチル]ピラゾロ[4,3-b][1,5]ベンゾジアゼピン-10(1H)-オン 化学特性,用途語,生産方法

• Originator

  Zolenzepine,ZYF Pharm Chemical

• Manufacturing Process

  3.5 g of 4-chloroacetyl-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3- b][1,5]benzodiazepin-10-one, 8.1 g of N-methylpiperazine and 50 ml of toluene are stirred at 80°C for 2 h. 60 ml of dilute sodium bicarbonate solution are added to the mixture, the layers are separated and the aqueous phase is extracted by shaking it with toluene several times more before concentrating it to dryness in vacuum. The residue is stirred with 100 ml of isopropanol and is filtered; the filtrate is concentrated in vacuum. The residue (4.0 g) is purified by stirring it with diethyl ether and by recrystallizing it from toluene, which yields 2.2 g of 1,3-dimethyl-4-[(4-methylpiperazin-1-yl)acetyl]-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one, melting point 186-188°C.

• Therapeutic Function

  Antiulcer

4,9-ジヒドロ-1,3-ジメチル-4-[(4-メチル-1-ピペラジニル)アセチル]ピラゾロ[4,3-b][1,5]ベンゾジアゼピン-10(1H)-オン 上流と下流の製品情報

4,9-ジヒドロ-1,3-ジメチル-4-[(4-メチル-1-ピペラジニル)アセチル]ピラゾロ[4,3-b][1,5]ベンゾジアゼピン-10(1H)-オン 生産企業

Global(1)Suppliers

78208-13-6, 4,9-ジヒドロ-1,3-ジメチル-4-[(4-メチル-1-ピペラジニル)アセチル]ピラゾロ[4,3-b][1,5]ベンゾジアゼピン-10(1H)-オン キーワード