N-[4-[2-[[(6R)-2-アミノ-3,4,5,6,7,8-ヘキサヒドロ-4-オキソピリド[2,3-d]ピリミジン]-6-イル]エチル]ベンゾイル]-L-グルタミン酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

• 注意書き

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

N-[4-[2-[[(6R)-2-アミノ-3,4,5,6,7,8-ヘキサヒドロ-4-オキソピリド[2,3-d]ピリミジン]-6-イル]エチル]ベンゾイル]-L-グルタミン酸 価格

N-[4-[2-[[(6R)-2-アミノ-3,4,5,6,7,8-ヘキサヒドロ-4-オキソピリド[2,3-d]ピリミジン]-6-イル]エチル]ベンゾイル]-L-グルタミン酸 化学特性,用途語,生産方法

• 説明

  Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol is a folate analog antimetabolite with antineoplastic activity. At nanomolar conentrations, it inhibits GART preventing de novo purine synthesis, inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.

• 使用

  Lometrexol hydrate was used to compare the biological activity of potent inhibitor of human GARFTase.

• Biochem/physiol Actions

  Glycinamide Ribonucleotide Formyltransferase (GARFTase) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexate is a potent inhibitor of GARFTase, but does not interfere with enzymes involved in the synthesis of folate. Lometrexerol has been tested clinically for the treatment of various cancers as an anti-folate like agent, similar to methotrexate. Treatment with lometrexol rapidly decreases ATP and GTP levels, cell cycle arrest and induces apoptosis. Although depletion of nucleotide pools induces p53 expression, lometrexol is cytotoxic in both wild-type and mutant p53 expressing tumor cells. Lometrexol is cytotoxic in CCRF-CEm leukemia cells with an IC50 of 2.9 nM.

N-[4-[2-[[(6R)-2-アミノ-3,4,5,6,7,8-ヘキサヒドロ-4-オキソピリド[2,3-d]ピリミジン]-6-イル]エチル]ベンゾイル]-L-グルタミン酸 生産企業

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N-[4-[2-[[(6R)-2-アミノ-3,4,5,6,7,8-ヘキサヒドロ-4-オキソピリド[2,3-d]ピリミジン]-6-イル]エチル]ベンゾイル]-L-グルタミン酸 スペクトルデータ(¹HNMR)

106400-81-1, N-[4-[2-[[(6R)-2-アミノ-3,4,5,6,7,8-ヘキサヒドロ-4-オキソピリド[2,3-d]ピリミジン]-6-イル]エチル]ベンゾイル]-L-グルタミン酸 キーワード