(3R)-3-ベンジルオキシピロリジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H332：吸入すると有害

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

(3R)-3-ベンジルオキシピロリジン 価格

(3R)-3-ベンジルオキシピロリジン 化学特性,用途語,生産方法

• 合成

  After N-tert-butoxycarbonyl-(R)-3-benzyloxypyrrolidine separately obtained was dissolved in isopropanol and heated to 40 °C, isopropanol solution of hydrogen chloride was dropped for 6 hours. After the reaction finished, the mixture was cooled to 23 °C and was concentrated to distil the solvent away. Further, ethyl acetate was added and the mixture was concentrated, thereby obtaining a concentrate in an amount of about. Then, the concentrate was heated to 40 °C, and isopropanol was added until (R)-3-benzyloxypyrrolidine hydrochloride which had been separated as an oily substance became completely dissolved. After (R) -3-benzyloxypyrrolidine hydrochloride was crystallized by gradually cooling the solution and suitably adding a seed crystal, hexane was further added. At the time, crystallization solvent was in a following proportion: isopropanol/ethyl acetate/hexane = 1/71.5/71.5. A deposited crystal was subjected to filtration under reduced pressure, and the resultant wet crystal was washed with ethyl acetate, and then a wet crystal was dried under reduced pressure, thereby obtaining dry crystal of (R)-3-benzyloxypyrrolidine hydrochloride (yield of 82 %, purity of 99.8 %).
  

(3R)-3-ベンジルオキシピロリジン 生産企業

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