SR-11302

SR-11302 価格

SR-11302 化学特性,用途語,生産方法

• 説明

  The receptors for retinoids, RARs and RXRs, induce transcriptional activation by binding the specific retinoid response elements, RARE and RXRE. Alternatively, retinoid receptors interact with and modulate other transcription factors, including activator protein-1 (AP-1). SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE. It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 μM). SR 11302 is used to elucidate the role of AP-1 in various signaling pathways.

• 使用

  SR 11302 is an inhibitor of activator protein-1.

• 生物活性

  Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo . Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC 50 > 1 μ M for RAR α , RAR β , RAR γ and RXR α ).

SR-11302 生産企業

Global(73)Suppliers

160162-42-5, SR-11302 キーワード