キシメラガトラン

キシメラガトラン 価格

キシメラガトラン 化学特性,用途語,生産方法

• 効能

  抗凝固薬, トロンビン阻害薬

• 説明

  Ximelagatran is an ester prodrug of melagatran, a potent, direct, and reversible thrombin inhibitor (K_i = 1.2 nM). While melagatran has poor oral bioavailability, ximelagatran displays good bioavailability resulting, in part, from rapid absorption at the gastrointestinal tract, as well as rapid onset of action. Ximelagatran is converted to melagatran by reduction and hydrolysis at the liver and other tissues. It is used as an anticoagulant in a variety of situations, including thromboembolic disorders, stroke prevention in atrial fibrillation, and therapy in vein thrombosis.

• 化学的特性

  Off-White Amorphous Solid

• 定義

  ChEBI: A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted to the corresponding ethyl ester and in which the amidine group has been converted to the corresponding amidoxime. A prodrug for melagatran, ximela atran was the first orally available direct thrombin inhibitor to be brought to market as an anticoagulant, but was withdrawn in 2006 following reports of it causing liver damage.

キシメラガトラン 生産企業

Global(63)Suppliers

キシメラガトラン スペクトルデータ(¹HNMR)

192939-46-1, キシメラガトラン キーワード