4-アセチルピペリジン-1-カルボン酸TERT-ブチル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

• 注意書き

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

4-アセチルピペリジン-1-カルボン酸TERT-ブチル 価格

4-アセチルピペリジン-1-カルボン酸TERT-ブチル 化学特性,用途語,生産方法

• 使用

  tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

• 合成

  Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).

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4-アセチルピペリジン-1-カルボン酸TERT-ブチル スペクトルデータ(¹HNMR、FT-IR)

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