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ネオテーム

ネオテーム 化学構造式
165450-17-9
  • CAS番号.165450-17-9
  • 化学名:ネオテーム
  • 别名:ネオテーム;ネオタム;ネオタム-D3
  • 英語化学名:Neotame
  • 英語别名:NEOTAME;Neutame.;NEOTAME (200 MG);Neotame fandachem;Neotame USP/EP/BP;NEOTAME 165450-17-9;Sweet Additives Neotame;Neotame Solution in Water, 100μg/mL;CAS 165450-17-9 Food Additive Sweeteners Neotame E961;L-Phenylalanine,N-(3,3-diMethylbutyl)-L-a-aspartyl-,2-Methyl ester
  • CBNumber:CB7500392
  • Molecular Formula:C20H30N2O5
  • Formula Weight:378.46
  • MOL File:165450-17-9.mol
ネオテーム 物理性質
  • 融点  :83-85°C
  • 比旋光度  :D -54.84° (c = 1 in methanol); D20 -39.8° (c = 0.5 in water)
  • 沸点  :565.3±50.0 °C(Predicted)
  • 比重(密度)  :1.133±0.06 g/cm3(Predicted)
  • 貯蔵温度  :Keep in dark place,Sealed in dry,2-8°C
  • 外見  :neat
  • 酸解離定数(Pka) :pKa1 3.01; pKa2 8.02(at 25℃)
  • 光学活性 (optical activity) :[α]/D -41.0±3.0°, c = 0.5 in H2O
  • BRN  :8352678
  • InChIKey :HLIAVLHNDJUHFG-HOTGVXAUSA-N
安全性情報
ネオテーム 価格 もっと(18)
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01COBOR-2777
  • 製品説明 : ネオタム
  • 純度: Neotame
  • 包装: 5g
  • 価格: ¥3600
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01COBOR-2777
  • 製品説明 : ネオタム
  • 純度: Neotame
  • 包装: 1g
  • 価格: ¥6600
  • 更新時間: 2020/09/21
  • 購入: 購入
  • メーカー: 東京化成工業
  • 製品番号: N1112
  • 製品説明 : ネオテーム
  • 純度: Neotame >98.0%(HPLC)(T)
  • 包装: 1g
  • 価格: ¥5000
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 東京化成工業
  • 製品番号: N1112
  • 製品説明 : ネオテーム
  • 純度: Neotame >98.0%(HPLC)(T)
  • 包装: 5g
  • 価格: ¥17000
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: Sigma-Aldrich Japan
  • 製品番号: 49777
  • 製品説明 : ネオテーム
  • 純度: Neotameanalytical standard
  • 包装: 100mg
  • 価格: ¥18800
  • 更新時間: 2021/03/23
  • 購入: 購入

Neotame 化学特性,用途語,生産方法

  • 外観 白色~ほとんど白色粉末~結晶
  • 定義 本品は、次の化学式で表される有機化合物である。
  • 化粧品の成分用途 香味剤
  • 化学的特性 Neotame occurs as an odorless, white to off-white powder. It has an intense sweet taste 7000–13 000 times sweeter than sucrose depending on the matrix.
  • 化学的特性 Neotame is odorless and has an intense, sweet taste. It is 7,000 to 13,000 times sweeter than sucrose, depending on the food matrix. Normal metabolic processes convert neotame to de-esterified neotame and methanol. Based on its metabolism and extremely low use levels, neotame provides no calories. The stability of neotame is affected by moisture, pH and temperature
  • 使用 Neotame is a high intensity sweetener and flavor enhancer for use in foods, except in meat and poultry. it is 7,000–13,000 times sweeter than sugar and has a clean, sweet taste. it is a derivative of the dipep- tide composed of amino acids, aspartic acid, and phenylalanine. it can be blended with nutritive sweeteners such as sucrose and high fructose corn syrup as well as with high intensity sweeteners such as aspartame and sucralose. uses include beverages, baked goods, desserts, cereals. it functions as a flavor enhancer in certain applica- tions and flavor systems, such as mint-flavored chewing gum.
  • 使用 An alkylated dipeptide reported to be 6000 to 10000 times sweeter than sucrose; structurally related to Aspartame. A non-nutritive sweetener.
  • 使用 A labelled alkylated dipeptide reported to be 6000 to 10000 times sweeter than sucrose; structurally related to Aspartame. A non-nutritive sweetener.
  • 定義 ChEBI: A dipeptide composed of N-(3,3-dimethylbutyl)-L-aspartic acid and methyl L-phenylalanate units joined by a peptide linkage.
  • 製造方法 Neotame is manufactured by the reaction of aspartame and 3,3-dimethylbutyraldehyde, followed by purification, drying and milling
  • 調製方法 Neotame is manufactured by the reaction of aspartame and 3,3- dimethylbutyraldehyde, followed by purification, drying, and milling.
  • 応用例(製薬) Neotame is a water-soluble, nonnutritive, intense sweetening agent used in beverages and foods. It is structurally related to aspartame and is about 7000–13 000 times sweeter than sucrose, and about 30–60 times sweeter than aspartame, making it the sweetest artificial sweetener available. Neotame is said to have a ‘clean’ sweet taste in contrast to the bitter, metallic aftertaste associated with saccharin. Although neotame has approximately the same caloric value as sucrose (1.2 kJ/g) the small quantities used to achieve a desired level of sweetness in a formulation mean that it is essentially nonnutritive.
    Neotame may be used in sub-sweetening quantities as a flavor enhancer, e.g. with mint or strawberry flavor.
  • 安全性 Neotame is a nonnutritive intense sweetening agent used in beverages and foods. Studies in animals and humans have shown that neotame is a relatively nontoxic, nonteratogenic, and noncarcinogenic substance. It is reported as safe for use during pregnancy and lactation, and by children and persons with diabetes.
    At least 30% of ingested neotame is rapidly absorbed. Neotame is metabolized to de-esterified neotame and methanol, with practically all neotame being eliminated from the body in the urine and feces. Peak plasma concentrations of neotame are observed at approximately 30–60 minutes after ingestion. Human studies in healthy and diabetic patients suggest that neotame is well-tolerated at doses up to 1.5 mg/kg body-weight daily (the highest dose studied). Following reviews of over 100 animal and human toxicity studies the European Food Safety Authority and WHO have established an acceptable daily intake for neotame at up to 2 mg/kg body-weight.
  • 貯蔵 Neotame is stable in bakery products and pasteurized dairy products.
    The bulk material should be stored in a well-closed container, in a cool, dry place; it is stable for up to 5 years at room temperature.
  • 規制状況(Regulatory Status) Accepted for use as a food additive in several countries including the USA, Mexico, Australia, and New Zealand. Approved for use in India in pharmaceutical preparations.
ネオテーム 上流と下流の製品情報
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165450-17-9, ネオテーム キーワード:
  • 165450-17-9
  • Neutame.
  • NEOTAME (200 MG)
  • N-(N-(3,3-Dimethylbutyl)-L-alpha-aspartyl)-L-phenylalanine 1-methyl ester
  • L-PHENYLALANINE, N-[N-(3,3-DIMETHYLBUTYL)-L-.ALPHA.-ASPARTYL]-, 1-METHYL ESTER
  • N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester
  • (S)-3-((3,3-DiMethylbutyl)aMino)-4-(((S)-1-Methoxy-1-oxo-3-phenylpropan-2-yl)aMino)-4-oxobutanoic acid
  • L-Phenylalanine,N-(3,3-diMethylbutyl)-L-a-aspartyl-,2-Methyl ester
  • L-Phenylalanine, N-(3,3-dimethylbutyl)-L-α-aspartyl-, 2-methyl ester
  • Neotame fandachem
  • Neotame Solution in Water, 100μg/mL
  • NEOTAME 165450-17-9
  • Neotame USP/EP/BP
  • Sweet Additives Neotame
  • NEOTAME
  • CAS 165450-17-9 Food Additive Sweeteners Neotame E961
  • ネオテーム
  • ネオタム
  • ネオタム-D3