シクロヘキシルイソシアニド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

シクロヘキシルイソシアニド 価格

シクロヘキシルイソシアニド 化学特性,用途語,生産方法

• 外観

  無色～うすい黄褐色、液体

• 化学的特性

  colourless liquid

• 使用

  Cyclohexyl Isocyanide can be used as novel arginase inhibitors to treat diseases.

• 製造方法

  CAUTION: Use a well-ventilated hood and take all precautions before using phosgene.
  To a flask equipped as in Preparation 3-1 is added 1.27 kg (10.0 moles) of N-cyclohexylformamide, 3.20 liters of triethylamine, and 4.50 liters of methylene chloride. The solution is stirred while phosgene is rapidly added (300-400 gm/hr) to cause vigorous refluxing. Refluxing ceases after 1.04 kg (10.2 moles) of phosgene have been added and the addition is stopped. The reaction mixture is cooled to 22-25°C, 400 gm (23.5 moles) of ammonia gas added over a period of 1-2 hr, the mixture filtered then concentrated under reduced pressure, and the residue distilled to afford 955 gm (88%), b.p. 67-72°C (14 mm Hg).
  

• 一般的な説明

  Cyclohexyl isocyanide reacts with dimethyl acetylenedicarboxylate to give a mixture of cyclopenta[b]pyridine derivatives, azaspirononatriene derivative and the azabicyclononatriene. It reacts with dialkyl acetylenedicarboxylates to form 1:1 intermediate which on facile addition to 1-benzylisatin and tryptantrin yields highly functionalized novel unsaturated γ-spiroiminolactones.

• 参考文献

  [1] Khalili, Gholamhossein. “ChemInform Abstract: A Diastereoselective Synthesis of (Z)-3-[(Aryl)(hydroxyimino)methyl] -2-cyclohexyl-1-(cyclohexylamino)imidazo[5,1-a]isoquinolinium Chlorides from Isoquinoline, Chlorooximes, and Cyclohexyl Isocyanide.” ChemInform 47 25 (2016).
  [2] M. Anary‐Abbasinejad, M. Heidari, N. Shams. “One-pot synthesis of highly functionalised 1H-pyrazoles from arylcarbohydrazides, cyclohexyl isocyanide, and acetylene diesters.” Arkivoc 2012 1 (2012).
  [3] Anary‐Abbasinejad, M. M. Jaafari and Mahdiyeh Talebizadeh. “One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives.” 2019. 0.
  [4] Alireza Hassanabadi. “ChemInform Abstract: Use of Cyclohexyl Isocyanide in the Esterification of N-Benzoyl α-Amino Acid Derivatives.” ChemInform 43 3 (2011).
  [5] A. Hassanabadi. “The use of cyclohexyl isocyanide in the esterification of N -benzoyl α-amino acids derivatives.” Journal of Chemical Research-s 18 1 (2011): 468–470.

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