DLin-MC3-DMA

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

DLin-MC3-DMA 化学特性,用途語,生産方法

• 説明

  D-Lin-MC3-DMA (MC3, DLin-MC3-DMA) is a potent and ionizable cationic lipid. D-Lin-MC3-DMA is used for delivery of siRNA in vivo. DLin-MC3-DMA, or (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate , is one of the most utilized cationic lipids that is used for making Lipid Nano-Particles (LNPs). These lipids, can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA or small molecules into the cytoplasm and represent the most advanced delivery platforms for systemic administration of active molecules.

• 使用

  DLin-M-C3-DMA is a commonly used drug delivery vehicle for the fabrication of lipid nanoparticles (LNPs), which exert therapeutic effects by encapsulating and delivering siRNA, mRNA, DNA, or small molecules into the cytoplasm of the cell, and is a potent siRNA delivery vehicle.

• 定義

  (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate (DLin-MC3-DMA or MC3, liquid oil) was identified as one of the most promising ionizable lipids due to its high transfection efficiency and is used in the first FDA-approved drug for the treatment of amyloidosis. In 2020, Ermilova et al. derived parameters for MC3 in combination with the Slipids force field. Unfortunately, the authors did not parametrize the protonated state of the MC3 molecule. Since MC3 has an apparent pKa of about 6.44, the protonated state plays an essential role: it ensures efficient encapsulation of the nucleic acids at low pH and a high charge at endosomal pH, enabling the drug release from the LNP. At physiological pH, the MC3 lipids are neutral, enabling the circulation of largely uncharged LNPs. For the modelling, it is beneficial to parametrize both states simultaneously[1].

• 生物活性

  DLin-MC3-DMA is an ionizable lipid used in combination with other lipids for encapsulation of RNA and DNA into lipid nanoparticles (LNPs). Administration of DLin-MC3-DMA based LNPs have delivered siRNA and reduced Factor VII levels in mice. Delivery of BCR-ABL siRNA reduced leukemic burden in a mouse model of chronic myeloid leukemia (CML).

DLin-MC3-DMA 上流と下流の製品情報

DLin-MC3-DMA 生産企業

Global(149)Suppliers

DLin-MC3-DMA スペクトルデータ(¹HNMR、MS)

1224606-06-7, DLin-MC3-DMA キーワード