4-(メチルヒドロキシホスフィニル)-L-Abu-L-Ala-L-Ala-OH 化学構造式

4-(メチルヒドロキシホスフィニル)-L-Abu-L-Ala-L-Ala-OH

化学名:4-(メチルヒドロキシホスフィニル)-L-Abu-L-Ala-L-Ala-OH

CAS番号.35597-43-4

英語名:BIALAPHOS

CBNumberCB7329454

MFC11H22N3O6P

MW323.28

MOL File35597-43-4.mol

别名

ビアラホス

抗生物質SF-1293

4-(メチルホスホニル)-L-Abu-L-Ala-L-Ala-OH

4-(メチルヒドロキシホスフィニル)-L-Abu-L-Ala-L-Ala-OH物理性質

融点	159-161 C
沸点	793.2±60.0 °C(Predicted)
比重(密度)	1.330±0.06 g/cm3(Predicted)
貯蔵温度	Store dry at -4
外見	固体
酸解離定数(Pka)	2.86±0.50(Predicted)
シーケンス	{phosphinothricin}-Ala-Ala

安全性情報

主な危険性	Xn
Rフレーズ	20/21/22-36/37/38
Sフレーズ	26-36

危険有害性情報のコード(GHS)

絵表示(GHS)
注意喚起語

Warning
危険有害性情報

H302：飲み込むと有害

H315：皮膚刺激

H319：強い眼刺激

H335：呼吸器への刺激のおそれ
注意書き

P264：取扱い後は皮膚をよく洗うこと。

P264：取扱い後は手や顔をよく洗うこと。

P270：この製品を使用する時に、飲食または喫煙をしないこと。

P280：保護手袋/保護衣/保護眼鏡/保護面を着用すること。

P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡すること。

P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコンタクトレンズを着用していて容易に外せる場合は外すこと。その後も洗浄を続けること。

P321：特別な処置が必要である（このラベルの．．．を見よ）。

P330：口をすすぐこと。

P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けること。

P362：汚染された衣類を脱ぎ、再使用す場合には洗濯をすること。

P501：内容物/容器を．．．に廃棄すること。

4-(メチルヒドロキシホスフィニル)-L-Abu-L-Ala-L-Ala-OH 化学特性,用途語,生産方法

説明
Bilanofos is a natural product formed during the fermentation of Streptomyces hygroscopicus. It is readily soluble in water and insoluble in organic solvents such as acetone, ethanol, benzene, and hexane (9).
Bilanophos is a GS inhibitor. In the plant, bilanofos is metabolized to L-glufosinate, which inhibits the enzyme GS. Ammonium ions rapidly accumulate in the plant, and photosynthesis is inhibited, leading to rapid death of the plant. It is inactivated in soil.
来歴
Bialaphos[peptide derivative of PPT (PPT linked to two L-alanine moieties)] was originally isolated from cultures of Streptomyces viridochromogenes (87) and Streptomyces hygroscopicus (88). L-PPT is the natural isomer, and it was the first natural amino acid found to contain a phosphinic group. PPT strongly inhibited glutamine synthetase activity in E. coli (87), and Hoechst Ag patented it as a herbicide after its phytotoxicity was discovered (89). Bialaphos was patented as a herbicide (90) and is marketed in Japan (91). Glufosinate (ammonium salt of PPT) is the synthesized commercial product. Bialaphos is hydrolyzed by plant and soil microbial peptidases to yield the active herbicide (PPT) (92–94). PPT is also rapidly degraded, with half-life of 4 to 7 days in soils (95). In a test of 300 bacterial isolates from soil, all strains degraded L-PPT to the 2-oxo analog of PPT via transamination (96).
定義
ChEBI: A tripeptide comprising one L-phosphinothricyl and two L-alanyl units joined in sequence.
Origin
The compound was launched as a nonselective contact herbicide in 1984.
代謝経路
When 14C-bialaphos [L-2-amino-4- [(hydroxy)(methyl)phosphinoyl]butyryl-L-alanyl-L- alanine] is administered in an aqueous solution to mice, the metabolite of bialaphos which is identified as 2-amino-4-[(hydroxy)(methyl)phosphinoyl]butyric acid is excreted in the feces and urine.
代謝
The major metabolite following oral administration in the mouse was 2-amino-4- (hydroxy)(methyl)phosphinyl)butyric acid, which was eliminated in feces.

4-(メチルヒドロキシホスフィニル)-L-Abu-L-Ala-L-Ala-OH 生産企業

35597-43-4, 4-(メチルヒドロキシホスフィニル)-L-Abu-L-Ala-L-Ala-OH キーワード

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