チロシジン

チロシジン 価格

チロシジン 化学特性,用途語,生産方法

• 解説

  チロシジン,Aの塩酸塩は融点204～242 ℃．[α]_D－111°(50％ エタノール)．水に易溶，メタノールに微溶．いずれもグラム陽性菌および陰性菌に有効で，細胞質膜に作用して透過性を乱す．毒性はマウス最小致死量5 mg/kg(静脈)．

• 製造

  グラミシジンとともに，枯草菌Bacillus brevisの培養液から得られる環状ペプチド抗菌性物質の混合物．A，B，Cの3種類が知られている．

• 化学的特性

  White or almost white powder.

• 使用

  Tyrothricin is a complex of two unrelated peptide families, gramicidin complex and tyrocidines complex, produced by Bacillus brevis and discovered by Dubos in 1939. Typically, tyrothricin is composed of 20% of the linear pentadecylpeptide gramicidins and 80% of cyclic decapeptide tyrocidines. Both the gramicidins and tyrocidines act by disrupting bacterial cell wall integrity, but by differing mechanisms. Tyrothricin is used clinically for bacterial skin infections in some countries.

• 定義

  An antibiotic produced by growth of Bacillus brevis. It consists of a mixture of antibiotics, principally gramicidin and tyrocidine. Gramicidin is the more active component. Use is generally limited to local external applications. It is active against some Gram-positive bacteria, including species of pneumococci, streptococci, and staphylococci.

チロシジン 生産企業

Global(49)Suppliers

1404-88-2, チロシジン キーワード