4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene 価格

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene 化学特性,用途語,生産方法

• 使用

  5-Bromo-2-chloro-4'-ethoxydiphenylmethane is a hydrocarbon derivative and can be used as an intermediate for dapagliflozin.

• 合成

  Oxalyl chloride (0.8 mL) was added to a solution of 5-bromo-2-chlorobenzoic acid (2 g) in dichloromethane (20 mL) and dimethylformamide (0.2 mL) under a nitrogen atmosphere. The reaction mixture was stirred for one hour at 25° C to 30° C. After completion of the reaction, the reaction mixture was concentrated under a vacuum at 40° C to 45° C. to obtain an oily residue. The oily residue was dissolved in dichloromethane (20 mL) and cooled to 0° C. To this solution, phenol (1.1 mL) and aluminium chloride (2.3 g) were added at 0° C. to 5° C. The reaction mixture was stirred at 0° C to 5° C for 2 hours. The reaction mixture was allowed to warm to about 20° C, and triethylsilane (3.4 mL) was slowly added to it at the same temperature. The reaction mixture was stirred for about 36 hours from 20° C to 25° C. After completion of the reaction, 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene was obtained by further purification.

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene 上流と下流の製品情報

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene 生産企業

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461432-23-5, 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene キーワード