(3R,4S,5R,6R)-3,4,5-トリス((トリメチルシリル)オキシ)-6-(((トリメチルシリル)オキシ)メチル)テトラヒドロ-2H-ピラン-2-オン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

(3R,4S,5R,6R)-3,4,5-トリス((トリメチルシリル)オキシ)-6-(((トリメチルシリル)オキシ)メチル)テトラヒドロ-2H-ピラン-2-オン 価格

(3R,4S,5R,6R)-3,4,5-トリス((トリメチルシリル)オキシ)-6-(((トリメチルシリル)オキシ)メチル)テトラヒドロ-2H-ピラン-2-オン 化学特性,用途語,生産方法

• 化学的特性

  Pale yellow oil

• 使用

  2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is an antidiabetic agent and an intermediate of Dapagliflozin (D185370). 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone acts as a reagent in the synthesis of trans-cyclohexane-bearing C-glucose as sodium glucose co-transporter 2 inhibitors.

• 合成

  At present, the publicly reported synthesis process of 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is mainly prepared by the synthesis of D-gluconolactone and trimethylsilyl chloride in the presence of an acid-binding agent or the preparation of D-gluconolactone and hexamethyldisilazane in dichloromethane reflux. The former has problems such as high pH requirements, low atom economy, and severe pollution. In contrast, the latter has such problems as the large amount of hexamethyldisilazane used, the strong volatility of dichloroethane, and severe pollution. Therefore, Li et al. developed a method for preparing 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone, comprising the following operations: reacting D-gluconolactone with hexamethyldisilazane in an ionic liquid at standard pressure, and removing the ionic liquid by reduced pressure distillation after the reaction is completed to obtain 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone; the cation in the ionic liquid is an alkyl imidazolium ion, and the anion in the ionic liquid is hexafluorophosphate, tetrafluoroborate, tetrachloroaluminate or chloride ion.

(3R,4S,5R,6R)-3,4,5-トリス((トリメチルシリル)オキシ)-6-(((トリメチルシリル)オキシ)メチル)テトラヒドロ-2H-ピラン-2-オン 生産企業

Global(470)Suppliers

32384-65-9, (3R,4S,5R,6R)-3,4,5-トリス((トリメチルシリル)オキシ)-6-(((トリメチルシリル)オキシ)メチル)テトラヒドロ-2H-ピラン-2-オン キーワード