2-ブチンジアミド

化学名:2-ブチンジアミド

CAS番号.543-21-5

英語名:ACETYLENEDICARBOXAMIDE

CBNumberCB7103786

MFC4H4N2O2

MW112.09

MOL File543-21-5.mol

别名

アセチレンジカルボン酸アミド

アセチレンジカルボアミド

セロシジン

2-ブチンジアミド物理性質

融点	179 °C
沸点	209.98°C (rough estimate)
比重(密度)	1.4421 (rough estimate)
屈折率	1.4610 (estimate)
貯蔵温度	Store at -20°C
溶解性	DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
外見	微結晶性粉末
酸解離定数(Pka)	13.01±0.50(Predicted)
色	クリーム～ベージュ
EPAの化学物質情報	2-Butynediamide (543-21-5)

安全性情報

主な危険性	T
Rフレーズ	25-21
Sフレーズ	45-36/37-28A
TSCA	TSCA listed
HSコード	29241900
毒性	LD50 i.v. in mice: 11 mg/kg (Suzuki)

危険有害性情報のコード(GHS)

2-ブチンジアミド化学特性,用途語,生産方法

説明
Cellocidin is an antibiotic originally isolated from S. chibaensis. It is active against various bacterial strains including M. tuberculosis and against the trypanosomes T. brucei and T. rhodesiense (IC₅₀s = 150 and 30 ng/ml, respectively). It inhibits proliferation of LCL1 and LCL2 cells transformed by Epstein-Barr virus (EBV), activates the c-Myc and NF-κB pathways in BC3 and LCL1 cells, and induces necrotic cell death in B cells infected with gammaherpes virus. Cellocidin (100-200 ppm) is protective against bacterial leaf blight in rice plants and inhibits α-ketoglutarate oxidation in X. oryzae, the bacterium that causes leaf blight, when used at a concentration of 1 ppm, suggesting that it inhibits the citric acid cycle. Formulations containing cellocidin have been used as agricultural pesticides.
化学的特性
CREAM TO BEIGE FINE CRYSTALLINE POWDER
使用
Cellocidin is a small neutral alkyne produced by a number of Streptomyces species, first discovered by Suzuki and colleagues in 1958. Cellocidin has a broad antibacterial, antifungal and antitumor profile due to its ability to react with endogenous thiols like cysteine and glutathione. Cellocidin occurs as a weak active in many bioassays using actinomycete crude extracts and is thus a useful standard for chemical and bioassay dereplication.
定義
ChEBI: A dicarboxylic acid diamide resulting from the formal condensation of both of the carboxy groups of butynedioic acid with ammonia. An antibacterial agent produced by Streptomyces chibaensis.
純化方法
Acetylenedicarboxamide crystallises from MeOH and H2O [m 190-192o(dec) as hemihydrate]. When prepared from the ester + NH3 it has m 213o(dec). Also a melting point of 290-292o(dec) has been reported. [Saggimo J Org Chem 22 1171 1857, Kharash et al. J Org Chem 10 392 1945, Blomquist & Winslow J Org Chem 10 156 1945, Beilstein 2 I 317, 2 III 1995, 2 IV 2295.]

2-ブチンジアミド

危険有害性情報のコード(GHS)

2-ブチンジアミド化学特性,用途語,生産方法

2-ブチンジアミド上流と下流の製品情報

2-ブチンジアミド生産企業

2-ブチンジアミドスペクトルデータ(IR1、IR2、MS)

543-21-5, 2-ブチンジアミドキーワード

2-ブチンジアミド

危険有害性情報のコード(GHS)

2-ブチンジアミド 化学特性,用途語,生産方法

2-ブチンジアミド 上流と下流の製品情報

2-ブチンジアミド 生産企業

2-ブチンジアミド スペクトルデータ(IR1、IR2、MS)

543-21-5, 2-ブチンジアミド キーワード

2-ブチンジアミド化学特性,用途語,生産方法

2-ブチンジアミド上流と下流の製品情報

2-ブチンジアミド生産企業

2-ブチンジアミドスペクトルデータ(IR1、IR2、MS)

543-21-5, 2-ブチンジアミドキーワード