ヘキサクロロ-1,3-ブタジエン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

  H310：皮膚に接触すると生命に危険

  H315：皮膚刺激

  H319：強い眼刺激

  H351：発がんのおそれの疑い

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ヘキサクロロ-1,3-ブタジエン 価格

ヘキサクロロ-1,3-ブタジエン 化学特性,用途語,生産方法

• 用途

  溶媒

• 説明

  Hexachlorobutadiene was first synthesized in 1877 by chlorination of hexyl iodide. It is an industrial by-product of tetrachloroethylene, trichloroethylene, and perchloroethylene production.

• 化学的特性

  colourless liquid (typical odour recognition threshold:

• 物理的性質

  Clear, yellowish-green liquid with a mild to pungent, turpentine-like odor. Odor threshold concentration is 6 ppb (quoted, Keith and Walters, 1992).

• 使用

  Hexachloro-1,3-butadiene is used as an urinary biomarker as a tool for early screening of potential kidney toxicity. Hexachloro-1,3-butadiene (HCBD) causes kidney injury.

• 一般的な説明

  A colorless liquid with a mild odor. Insoluble in water and denser than water. Nonflammable. May be toxic by ingestion or inhalation. Used as a solvent and heat transfer fluid.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Hexachloro-1,3-butadiene rapidly decomposes rubber on contact. Can react vigorously with oxidizing materials. Reacts to form an explosive product with bromine perchlorate. . Gives highly toxic and irritating chloride fumes when burned.

• 危険性

  Toxic by ingestion and inhalation, a questionable carcinogen.

• 健康ハザード

  Poisonous; may be fatal if inhaled, swallowed or absorbed through the skin. Inhalation causes repiratory difficulty and irritation of mucous membranes. Skin and eye irritant; may cause burns.

• 職業ばく露

  Hexachlorobutadiene is used as a sol vent; heat-transfer fluid; transformer fluid; hydraulic fluid; as a solvent for elastomers; as a wash liquor for removing higher hydrocarbons.

• 発がん性

  In rats given oral administration, it produced benign and malignant tumors in the kidneys in both sexes. The IARC then concluded that there is limited evidence that HCBD is carcinogenic in rats.
  Nakagawa et al. reported that HCBD is a potent nephrotoxicant that selectively damaged the straight portion (pars recta) of the proximal tubule in the rat. They also reported administering 0.1% HCBD for 30 weeks to male Wistar rats previously given 0.1% N-ethyl-N-hydroxyethylnitrosamine (EHEN) in their drinking water for 2 weeks and that the combined treatment resulted in a significantly higher incidence of renal cell tumors than when EHEN was administered alone.

• 環境運命予測

  Chemical/Physical. Hexachlorobutadiene will not hydrolyze to any reasonable extent (Kollig, 1993).
  At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 258, 91, 21, and 11 mg/g, respectively (Dobbs and Cohen, 1980).

• 代謝経路

  In the presence of glutathione (GSH), mouse liver microsomes and cytosol transform 14C-hexachloro- 1,3-butadiene (HCBD) to S- (pentachlorobutadienyl)glutathione (PCBG). PCBG formation in subcellular fractions from a mouse kidney is very limited. After an oral dose of HCBD to mice, PCBG in feces, and S-(pentachlorobutadienyl)-L- cysteine, N-acetyl-S-(pentachlorobutadienyl)-L- cysteine, and 1,1,2,3-tetrachlorobutenoic acid in the urine are identified as the metabolites.

• 輸送方法

  UN2279 Hexachlorobutadiene, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• 純化方法

  Wash the diene with four or five 1/10th volumes of MeOH (or until the yellow colour has been extracted), then stir it for 2hours with H2SO4, wash it with distilled water until neutral and filter it through a column of P2O5. Distil it under reduced pressure through a packed column. [Rytner & Bauer J Am Chem Soc 82 298 1960, Beilstein 1 IV 998.]

• 不和合性

  Strong reaction with oxidizers, aluminum powder. Attacks aluminum; some plastics, rubber and coatings

• 廃棄物の処理

  High temperature incineration with flue gas scrubbing. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.

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