グアニジン塩酸塩

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

グアニジン塩酸塩 価格

MSDS Information

• Guanidine hydrochloride

グアニジン塩酸塩 化学特性,用途語,生産方法

• 外観

  白色, 結晶〜結晶性粉末

• 定義

  本品は、グアニジンの塩酸塩であり、次の化学式で表される。

• 溶解性

  水に極めて溶けやすく、エタノールに溶けやすく、アセトンにほとんど溶けない。

• 用途

  サルファ剤原料、帯電防

• 用途

  RNA抽出用。

• 用途

  合成繊維用帯電防止剤,葉酸合成原料,サルファ剤合成原料,たん白質可溶化剤

• 用途

  タンパク変性剤。

• 用途

  たん白質変性剤。

• 用途

  たん白変性剤、たん白質研究用。

• 効能

  タンパク質変性剤

• 使用上の注意

  潮解性あり

• 化学的特性

  Guanidine hydrochloride, a strong organic base, appears as white crystal powder or yellowish lumps that are almost insoluble in acetone, benzene, and ether. In physiological pH, it exists primarily as guanidium ions. It is a natural byproduct of protein metabolism found in urine and is commonly used in protein denaturation in laboratory research.

• 使用

  Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

• 製造方法

  The process for preparing guanidine hydrochloride is as follows:
  Step 1: Fritting - Combine dicyandiamide and ammonium chloride in a reactor with a 1:1.27 weight ratio and carry out a frit reaction at 170-230°C to obtain crude guanidine hydrochloride.
  Step 2: Dissolving - Dissolve the crude guanidine hydrochloride in water at a 1:1 ratio at normal temperature. Then, add ammonium salt alkaloid in an amount determined by the ammonium salt content in the crude guanidine hydrochloride.
  Step 3: Filtering - Remove raw materials and reaction by-products with filtration.
  Step 4: Dehydrating - Dehydrate the filtered ground mother liquor at a high temperature.
  Step 5: Crystallizing - Cool the supersaturated solution, concentrate, and crystallize to obtain high-purity guanidine hydrochloride.
  Step 6: Repeat steps 2-5 and add dicyandiamide in the reactor with the guanidine hydrochloride to carry out frit reaction at 170-230°C for 3-4 hours to obtain even higher purity guanidine hydrochloride. This step can be repeated several times if needed.
  Step 7: To obtain higher purity guanidine hydrochloride, subject the guanidine hydrochloride obtained in step 5 to steps 2-5 again, with the water ratio in step 2 adjusted to 1.5:1. This step can be repeated numerous times as required.

• 定義

  ChEBI: Guanidine Hydrochloride is an aminocarboxamidine, the parent compound of the guanidines. It is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism.

• 一般的な説明

  Guanidine hydrochloride (GdnHCl) is a well-known protein and enzyme denaturant. It is a small molecule and hydroscopic in nature. It is used to synthesis medicine, pesticide, dye and other organic compound, is the important material to make sulfanilamide medicine and folacin, and can be used as anti-static agent of compound fibre.

• 危険性

  Toxic by ingestion, evolves hydrogen chloride fumes on heating.

• 純化方法

  Crystallise the hydrochloride from hot methanol by chilling to about -10o, with vigorous stirring. The fine crystals are filtered through fritted glass, washed with cold (-10o) methanol, dried at 50o under vacuum for 5hours. (The product is purer than that obtained by crystallisation at room temperature from methanol by adding large amounts of diethyl ether.) [Kolthoff et al. J Am Chem Soc 79 5102 1957, Beilstein 3 H 86, 3 II 71, 3 III 160, 3 IV 150.]

• 参考文献

  [1] MIKHAIL M. TIKHONOV Boris A N Alexander V Akentiev. Influence of guanidine hydrochloride and urea on the dynamic surface properties of lysozyme solutions[J]. Mendeleev Communications, 2015, 25 4: Pages 288-289. DOI:10.1016/j.mencom.2015.07.020. DOI:10.1016/J.MENCOM.2015.07.020.
  [2] M.M. TIHONOV B. A N O Yu Milyaeva. Dynamic surface properties of lysozyme solutions. Impact of urea and guanidine hydrochloride[J]. Colloids and Surfaces B: Biointerfaces, 2015, 129: Pages 114-120. DOI:10.1016/j.colsurfb.2015.03.034.DOI:10.1016/j.colsurfb.2015.03.034.
  [3] Use of Protein Folding Reagents[J]. Current Protocols in Protein Science, 2016, 84 1. DOI:10.1002/0471140864.psa03as84.
  [4] https://www.ncbi.nlm.nih.gov/mesh/68019791
  [5] [1] https://www.scbt.com/scbt/product/guanidine-hydrochloride-50-01-1
  [6] https://www.alfa.com/zh-cn/catalog/A13543/
  [7] https://www.researchgate.net/post/Protein_Denaturation_Urea_vs_Guanidine_Hydrochloride_GdnHCl
  [8] JON W. POULSEN. Using Guanidine-Hydrochloride for Fast and Efficient Protein Digestion and Single-step Affinity-purification Mass Spectrometry[J]. Journal of Proteome Research, 2012, 12 2: 1020-1030. DOI: 10.1021/pr300883y.

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グアニジン塩酸塩 スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

50-01-1, グアニジン塩酸塩 キーワード