ナフシリンナトリウム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H317：アレルギー性皮膚反応を起こすおそれ

  H334：吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P342+P311：呼吸に関する症状が出た場合：医師に連絡すること。

ナフシリンナトリウム 価格

ナフシリンナトリウム 化学特性,用途語,生産方法

• 使用

  As a synthetic beta-lactamase-resistant penicillin, Nafcillin SodiuM Salt can be used to treat infections caused by Gram-positive bacteria, in particular, species of staphylococci that are resistant to other penicillins.

• 適応症

  It is effective against Gram-positive cocci and staphylococci that produce penicillinase. It is used for the same indications as methicillin. Synonyms of this drug are nafcil, nalpen, unipen, and others.
  Another type of semisynthetic penicillin that should undoubtedly be considered is penicillin derivatives of heteroylcarboxylic acids (as a rule an isoxazol) in the third position of which is present a substituted or nonsubstituted phenyl radical (oxacillin, cloxacillin, dicloxacillin), which plays the role of the radical in the acyl side group. These penicillins (oxacillin, cloxacillin, dicloxacillin), which are resistant to penicillinase, are active with respect to penicillin-G-resistant staphylococci. Their antimicrobial spectrum is restricted to Gram-positive microorganisms.
  Penicillins that are resistant to penicillinase are the drug of choice for infections resistant to penicillin G, Staph. aureus, or coagulase-negative staphylococci. They are also effective for infections caused by nonenterococcus types of streptococci, such as streptococci groups A, B, C, and G, as well as pneumococci.

• 抗菌性

  The antibacterial spectrum is similar to that of the isoxazolylpenicillins but it is more active against streptococci and pneumococci. Activity in vitro is depressed in the presence of serum. It is more stable than the isoxazolylpenicillins to staphylococcal β-lactamase. There is complete cross-resistance with other group 3 penicillins.

• 薬物動態学

  Oral absorption: c. 35%
  C_max 1 g intramuscular:8 mg/L after 1 h
  500 mg intravenous:30 mg/L after 5 min
  Plasma half-life: 0.5 h
  Plasma protein binding: 90%
  Absorption and distribution
  Nafcillin is poorly absorbed after oral administration, and absorption is further depressed if the drug is given with food. Most dosing is now intravenous. Penetration into tissues is similar to that of the isoxazolylpenicillins. Penetration into normal meninges is low, but is higher in inflamed meninges.
  Metabolism and excretion
  About 60–70% is inactivated in the liver. Following intramuscular administration, about 30% appears in the urine, producing concentrations up to 1000 mg/L. Administration of probenecid reduces the urinary excretion and raises and prolongs the plasma level. About 8% of the dose is excreted in the bile.

• 臨床応用

  Uses are those of group 3 penicillins . Nafcillin has been particularly recommended for the treatment of staphylococcal bacteremia caused by susceptible strains.

• 副作用

  There is cross-allergenicity with other penicillins. Its side effects are similar to the penicillins. Pseudomembranous colitis has been reported.

ナフシリンナトリウム 上流と下流の製品情報

ナフシリンナトリウム 生産企業

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