FR122047塩酸塩

FR122047塩酸塩 価格

FR122047塩酸塩 化学特性,用途語,生産方法

• 説明

  FR122047 is a selective inhibitor of COX-1. The IC₅₀ values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC₅₀ of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

• 使用

  FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

• 生物活性

  Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .

FR122047塩酸塩 生産企業

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FR122047塩酸塩 スペクトルデータ(¹HNMR)

130717-51-0, FR122047塩酸塩 キーワード