1-(トリフルオロメチル)-1H,2H,3H,4H,9H-ピリド[3,4-b]インドール

1-(トリフルオロメチル)-1H,2H,3H,4H,9H-ピリド[3,4-b]インドール 化学特性,用途語,生産方法

• 作用機序

  Although βCCE and other β-carbolines are not endogenous BZR ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil) toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse agonist pharmacophores of the various GABAA/BZR subtypes.

• 臨床応用

  Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction procedure, has very high affinity for the BZR.

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1-(トリフルオロメチル)-1H,2H,3H,4H,9H-ピリド[3,4-b]インドール 生産企業

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112037-78-2, 1-(トリフルオロメチル)-1H,2H,3H,4H,9H-ピリド[3,4-b]インドール キーワード