モルヒネ硫酸塩水和物

化学名:モルヒネ硫酸塩水和物

CAS番号.6211-15-0

英語名:Morphine Sulfate

CBNumberCB6140018

MFC34H50N2O15S

MW758.83

MOL File6211-15-0.mol

别名

7,8-ジデヒドロ-4,5α-エポキシ-17-メチルモルフィナン-3,6α-ジオール·0.5硫酸塩·2.5水和物

モルフィン硫酸塩五水和物

モルヒネ硫酸塩水和物

モルヒネ硫酸塩水和物物理性質

融点	>240°C (dec.)
貯蔵温度	Controlled Substance, -20°C Freezer
溶解性	エタノール：1.8mg/mL
外見	A crystalline solid
BCS Class	3/1
主な用途	医薬品
InChIKey	GRVOTVYEFDAHCL-RTSZDRIGSA-N
SMILES	[S](=O)(=O)(O)O.N6([C@H]7[C@H]8[C@@]9([C@@H](Oc%10c9c(ccc%10O)C7)[C@H](C=C8)O)CC6)C.N1([C@H]2[C@H]3[C@@]4([C@@H](Oc5c4c(ccc5O)C2)[C@H](C=C3)O)CC1)C.O.O.O.O.O

安全性情報

主な危険性	Xn
Rフレーズ	22
Sフレーズ	22-36
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS 番号	QC8760000
HSコード	2939110000
ストレージクラス	11 - Combustible Solids
Hazard Classifications	Aquatic Chronic 2 Eye Irrit. 2 Repr. 2 Skin Irrit. 2 STOT SE 3

危険有害性情報のコード(GHS)

モルヒネ硫酸塩水和物化学特性,用途語,生産方法

効能
麻薬性鎮痛薬, オピオイド受容体作動薬
商品名
MSコンチン (シオノギファーマ); MSツワイスロン (帝國製薬); カディアン (大日本住友製薬)
説明
Morphine (sulfate hydrate) (Item No. 25955) is an analytical reference standard categorized as an opioid. It is a natural phenanthrene commonly used for its analgesic properties but has a high potential for addiction. Morphine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
化学的特性
White Solid
使用
Principal alkaloid of opium. This is a controlled substance (opiate). Analgesic (narcotic)
獲得抵抗性
The analgesic effect of orally dosed morphine can equal that obtained by parenteral administration, if proper doses are given. When given orally, the initial dose of morphine is usually 60 mg, followed by maintenance doses of 20 to 30 mg every 4 hours. Addiction to clinically used morphine by the oral route generally is not a problem.
作用機序
Morphine sulfate is the analgesic used most often for severe, acute, and chronic pain. Morphine is a μ agonist and is a Schedule II drug. It is available in intramuscular, subcutaneous, oral, rectal, epidural, and intrathecal dosage forms. The epidural and intrathecal preparations are formulated without a preservative.Morphine is three- to six times more potent when given intramuscularly than when given orally. The difference in activity results from extensive first-pass 3-O-glucuronidation of morphine—an inactive metabolite. The half-life of intramuscularly dosed (10 mg) morphine is approximately 3 hours. The dose of morphine, by any dosage route, must be reduced in patients with renal failure and in geriatric and pediatric patients. The enhanced effects of morphine in renal failure is believed to be caused by a buildup of the active 6-glucuronide metabolite, which depends on renal function for elimination.

6211-15-0, モルヒネ硫酸塩水和物キーワード

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モルヒネ硫酸塩水和物

危険有害性情報のコード(GHS)

モルヒネ硫酸塩水和物 化学特性,用途語,生産方法

6211-15-0, モルヒネ硫酸塩水和物 キーワード

モルヒネ硫酸塩水和物化学特性,用途語,生産方法

6211-15-0, モルヒネ硫酸塩水和物キーワード