4-[(2,4-ジヒドロキシ-3,6-ジメチルベンゾイル)オキシ]-2-ヒドロキシ-3,5,6-トリメチル安息香酸4-カルボキシ-3-ヒドロキシ-2,5,6-トリメチルフェニル

4-[(2,4-ジヒドロキシ-3,6-ジメチルベンゾイル)オキシ]-2-ヒドロキシ-3,5,6-トリメチル安息香酸4-カルボキシ-3-ヒドロキシ-2,5,6-トリメチルフェニル 化学特性,用途語,生産方法

• 説明

  Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H₂ (PGH₂; ) and the conversion of PGH₂ to PGE₂ (; IC₅₀s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC₅₀ = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC₅₀ = 23.8 μM; K_i = 27.8 μM).

• 使用

  The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.

4-[(2,4-ジヒドロキシ-3,6-ジメチルベンゾイル)オキシ]-2-ヒドロキシ-3,5,6-トリメチル安息香酸4-カルボキシ-3-ヒドロキシ-2,5,6-トリメチルフェニル 生産企業

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