チミジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

チミジン 価格

MSDS Information

• Thymine deoxyriboside

チミジン 化学特性,用途語,生産方法

• 外観

  白色～ほとんど白色、結晶～粉末

• 定義

  本品は、次の化学式で表される複素環式化合物である。

• 溶解性

  水,メタノール,熱エタノール,熱酢酸エチルなどに可溶。

• 解説

  チミジンピリミジンヌクレオシドの一つ．デオキシリボ核酸の成分である．"融点182～183 ℃．[α]_D＋18.5°(水)．pK1 9.8，pK2 12.9．λmax 267 nm(ε 9.65×103，pH 7.2)．水に易溶，ピリジンに可溶．LD50 2512 mg/kg(マウス，腹腔)．

• 用途

  核酸合成用、同調培養用試薬。

• 化粧品の成分用途

  皮膚コンディショニング剤

• 説明

  Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. In cell biology it is used to synchronize the cells in G₁/early S phase.

• 化学的特性

  White needle crystal, soluble in methanol, ethanol, DMSO and other organic solvents.

• 物理的性質

  Thymidine can exist in vitro conditions as a solid (as white crystals or as white crystalline powder). Under standard temperature and pressure, the stability of this compound is very high. As a part of DNA structure, thymidine occurs in living organisms (also in DNA viruses). Therefore, it is a non-toxic compound. In RNA, there is uridine instead of thymidine. Uridine is formed from the combination of uracil with ribose sugar. The key difference between thymine and thymidine is that thymine is a nucleobase, whereas thymidine is a nucleoside.

• 使用

  Thymidine is used in the syntheses of active pharmaceutical ingredient such as zidovudine. It also pairs with deoxyadenosine in double-stranded deoxyribonucleic acid. It is used to synchronize the cells in G1/early S phase in cell biology.

• 主な応用

  Some antiviral drugs, especially those targeting retroviruses such as HIV, are thymidine analogs. For example, zidovudine (AZT) is a thymidine analog that can be mistakenly used by viral reverse transcriptase to synthesize DNA, thereby interrupting the viral replication process.

• 定義

  ChEBI: Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a thymine. It is an enantiomer of a telbivudine.

• 一般的な説明

  Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine.

• 安全性プロファイル

  Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

• 概要

  dA，dC，およびdGとともにDNAを構成する主要ヌクレオシド，mp. 185 °C．水に可溶

• 純化方法

  Crystallise -thymidine from ethyl acetate, MeOH/Et2O (m 188o) or H2O (as 2H2O m 189o). It is soluble in water and hot organic solvents. The picrate has m 230o (from EtOH).

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