N-[2-[3-[(1,1-ジメチルエチル)アミノ]-2-ヒドロキシプロポキシ]フェニル]-2-フランカルボアミド

N-[2-[3-[(1,1-ジメチルエチル)アミノ]-2-ヒドロキシプロポキシ]フェニル]-2-フランカルボアミド 化学特性,用途語,生産方法

• Originator

  Ancarolol,ZYF Pharm Chemical

• Manufacturing Process

  A mixture of 23 g of 2'-(2,3-epoxypropoxy)-furan-2-carboxylic acid anilide, 7.3 g of t-butylamine and 50 ml of isopropanol is boiled under reflux for 10 hours. On cooling, 2'-(2-hydroxy-3-t-butylaminopropoxy)-furan-2-carboxylic acid anilide (ancarolol) crystallizes out from the solution. The chromatographically pure base is obtained in the form of a white solid of melting point 112°-113°C by recrystallization from ethyl acetate. The yield is 12 g. The colorless, crystalline base is dissolved in alcohol, alcoholic HCl is added and the hydrochloride is induced to crystallize by adding ether dropwise. After isolation, the salt is recrystallized again from ethanol. This gives 10 g of the hydrochloride, melting point 189°-191°C.

• Therapeutic Function

  Beta-adrenergic blocker

N-[2-[3-[(1,1-ジメチルエチル)アミノ]-2-ヒドロキシプロポキシ]フェニル]-2-フランカルボアミド 上流と下流の製品情報

N-[2-[3-[(1,1-ジメチルエチル)アミノ]-2-ヒドロキシプロポキシ]フェニル]-2-フランカルボアミド 生産企業

Global(13)Suppliers

75748-50-4, N-[2-[3-[(1,1-ジメチルエチル)アミノ]-2-ヒドロキシプロポキシ]フェニル]-2-フランカルボアミド キーワード