N,N-ビス(2-クロロエチル)-2-ナフチルアミン化学構造式

N,N-ビス(2-クロロエチル)-2-ナフチルアミン

化学名:N,N-ビス(2-クロロエチル)-2-ナフチルアミン

CAS番号.494-03-1

英語名:chlornaphazine

CBNumberCB5916238

MFC14H15Cl2N

MW268.185

MOL File494-03-1.mol

别名

N,N-ビス(2-クロロエチル)-2-ナフチルアミン

エリサン

クロロナフチナ

N,N-ビス(2-クロロエチル)-2-ナフチルアミン物理性質

融点	54-56°
沸点	bp5 210°
比重(密度)	1.2039 (rough estimate)
屈折率	1.6300 (estimate)
酸解離定数(Pka)	2.75±0.70(Predicted)
色	ペットエーテルからの血小板
IARC	1 (Vol. 4, Sup 7, 100A) 2012
EPAの化学物質情報	Chlornaphazine (494-03-1)

安全性情報

有毒物質データの	494-03-1(Hazardous Substances Data)
毒性	LD50 intraperitoneal in mouse: 1300mg/kg

N,N-ビス(2-クロロエチル)-2-ナフチルアミン化学特性,用途語,生産方法

用途
抗悪性腫瘍薬(白血病とホジキン病の治療において使われる)
化学的特性
Chlornaphazine is composed of clear, colorless plates or may be a brown solid.
世界保健機関（WHO）
The World Health Organization has no information further to the above regarding preparations containing chlornaphazine or to indicate that they are still commercially manufactured.
一般的な説明
Colorless plates or brown solid.
空気と水の反応
Insoluble in water.
反応プロフィール
chlornaphazine reacts with nucleophiles .
火災危険
Flash point data are not available for chlornaphazine , but chlornaphazine is probably combustible.
安全性プロファイル
Confirmed human carcinogenproducing bladder tumors. Human and experimentalcarcinogenic data. Moderately toxic by intraperitonealroute. When heated to decomposition it emits very toxicfumes of Cl- and NOx.
職業ばく露
May be combustible and possibly explosive. Not produced or used commercially in the United States, Chlornaphazine has been used in other countries in the treatment of leukemia and related cancers. Currently, this drug does not have wide therapeutic usage.
輸送方法
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
純化方法
Crystallise it from pet ether. At 15o it is soluble in EtOH (3.2%), Et2O (50%), Me2CO (84%) and *C6H6 (80%). [Beilstein 12 III 2996, 12 IV 3126.] CARCINOGENIC.
不和合性
Keep away from oxidizers, nucleophiles, and nitromethanes. Amines may react violently with nitric acid; cellulose nitrate (of high surface area); 1-chloro-2,3-epoxypropane (exothermic reaction may occur). Incompatible with acids, acid halides; alcohols, aldehydes, alkylene oxides; anhydrides, cresols, caprolactam solution; epichlorohydrin, epoxides, isocyanates, glycols, peroxides, phenols. Contact with strong reducing agents may generate flammable hydrogen gas. May attack copper and copper alloys.
廃棄物の処理
Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment. For proper handling and disposal, always comply with federal, state, and local regulations.

N,N-ビス(2-クロロエチル)-2-ナフチルアミン生産企業

494-03-1, N,N-ビス(2-クロロエチル)-2-ナフチルアミンキーワード

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N,N-ビス(2-クロロエチル)-2-ナフチルアミン

N,N-ビス(2-クロロエチル)-2-ナフチルアミン 化学特性,用途語,生産方法

N,N-ビス(2-クロロエチル)-2-ナフチルアミン 生産企業

494-03-1, N,N-ビス(2-クロロエチル)-2-ナフチルアミン キーワード

N,N-ビス(2-クロロエチル)-2-ナフチルアミン化学特性,用途語,生産方法

N,N-ビス(2-クロロエチル)-2-ナフチルアミン生産企業

494-03-1, N,N-ビス(2-クロロエチル)-2-ナフチルアミンキーワード