4-ヒドロキシ安息香酸ブチル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H315：皮膚刺激

  H318：重篤な眼の損傷

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

4-ヒドロキシ安息香酸ブチル 価格

MSDS Information

• 4-(Butoxycarbonyl)phenol

4-ヒドロキシ安息香酸ブチル 化学特性,用途語,生産方法

• 外観

  無色の結晶又は白色の結晶性の粉末

• 定義

  本品は、パラヒドロキシ安息香酸とブタノール(*)のエステルであり、次の化学式で表される。
  参照表示名称：ブタノール

• 溶解性

  水に難溶。エタノール, エーテルに可溶。エタノール及びアセトンに極めて溶けやすく、水に極めて溶けにくい。

• 無機性値/有機性値

  175/220

• 用途

  保存料。

• 化粧品の成分用途

  防腐剤、香料

• 効能

  防腐剤

• 主な用途／役割

  でんぷん系接着剤に使用される。

• 説明

  Butylparaben is an antimicrobial agent used in pharmaceutical suspensions. It is act by inhibiting DNA, RNA, and enzymes (eg, ATPase and phosphotransferase) synthesis. Butylparaben may be used alone or with other parabens, chiefly methylparaben and/or propylparaben, in medications. It is common in many liquid and solid (gel cap) OTC products such as Tylenol, Drixoral, Maalox, and Mylanta. Unfortunately, butylparaben concentrations were seldom identified for OTC or prescription products. No attempt was made to identify butylparaben-containing dietary supplements.

• 化学的特性

  Butylparaben occurs as colorless crystals or a white, crystalline, odorless or almost odorless, tasteless powder.

• 調製方法

  Butylparaben is prepared by esterification of p-hydroxybenzoic acid with n-butanol.

• 製造方法

  Butyl paraben is prepared by esterifying p-hydroxybenzoic acid with butyl alcohol in the presence of an acid catalyst, such as sulfuric acid, and an excess of the specific alcohol.

• 一般的な説明

  Odorless white crystals or crystalline powder. Tasteless, but numbs the tongue. Aqueous solutions slightly acidic to litmus.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Butylparaben is incompatible with strong oxidizing agents and strong caustics.

• 火災危険

  Flash point data for Butylparaben are not available; however, Butylparaben is probably combustible.

• 応用例（製薬）

  Butylparaben is widely used as an antimicrobial preservative in cosmetics and pharmaceutical formulations.
  It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics, it is the fourth most frequently used preservative.
  As a group, the parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
  Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used in formulations. However, this may raise the pH of poorly buffered formulations. See Methylparaben for further information.

• 接触アレルゲン

  This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

• 安全性

  Butylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics and oral and topical pharmaceutical formulations.
  Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions generally appearing as contact dematitis. Immediate reactions with urticaria and bronchospasm have occurred rarely. See Methylparaben for further information.
  LD₅₀ (mouse, IP): 0.23 g/kg
  LD₅₀ (mouse, oral): 13.2 g/kg

• 貯蔵

  Aqueous butylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).

• 不和合性

  The antimicrobial activity of butylparaben is considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of butylparaben by plastics has not been reported but appears probable given the behavior of other parabens. Some pigments, e.g. ultramarine blue and yellow iron oxide, absorb butylparaben and thus reduce its preservative properties.
  Butylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

• 規制状況(Regulatory Status)

  Butylparaben is regulated by the U.S. Environmental Protection Agency (EPA) under the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). In 1998 its pesticide registration status was listed as "cancelled" (U.S. EPA, 2003).
  Included in the FDA Inactive Ingredients Database (injections; oral capsules, solutions, suspensions, syrups and tablets; rectal, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

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