(Z)-2-メチル-2-ブテン酸[(1S,2R,7aR)-ヘキサヒドロ-2β-ヒドロキシ-1H-ピロリザイン-1β-イル]メチル

(Z)-2-メチル-2-ブテン酸[(1S,2R,7aR)-ヘキサヒドロ-2β-ヒドロキシ-1H-ピロリザイン-1β-イル]メチル 化学特性,用途語,生産方法

• 説明

  A pyrrolizidine alkaloid, macrophylline has been isolated from Senecio amphibolus and S. macrophylla MB. It forms a low melting solid which has not yet been obtained in a crystalline form. The base is dextrorotatory having a specific rotation of [α]²⁰_D + 34.52° (c 1.68, EtOH). When hydrolyzed with dilute acids the base furnishes macronecine and angelic acid. It has been characterized as the crystalline bitartrate which melts at 162-4°C.

• 参考文献

  Danilova et al.,J. Gen. Chem. USSR, 23,1417 (1953)
  Danilova, Kuzovkov, ibid, 23,1597 (1953)
  Danilova, Utkin, Massagetov, ibid, 25, 797 (1955)
  Danilova, Utkin, ibid, 30, 345 (1960)
  Culvenor, Geissman,J. Org. Chem., 26, 3045 (1961)

(Z)-2-メチル-2-ブテン酸[(1S,2R,7aR)-ヘキサヒドロ-2β-ヒドロキシ-1H-ピロリザイン-1β-イル]メチル 生産企業

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