4-クロロ-2-[3-[3-(トリフルオロメチル)フェニル]ウレイド]安息香酸

4-クロロ-2-[3-[3-(トリフルオロメチル)フェニル]ウレイド]安息香酸 価格

4-クロロ-2-[3-[3-(トリフルオロメチル)フェニル]ウレイド]安息香酸 化学特性,用途語,生産方法

• 説明

  Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC₅₀ value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.

• 使用

  NS3694 is a suppressor of the formation of apoptosome Apaf-1.

4-クロロ-2-[3-[3-(トリフルオロメチル)フェニル]ウレイド]安息香酸 生産企業

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4-クロロ-2-[3-[3-(トリフルオロメチル)フェニル]ウレイド]安息香酸 スペクトルデータ(¹HNMR)

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