rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H319：強い眼刺激

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P273：環境への放出を避けること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P501：内容物/容器を．．．に廃棄すること。

rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール 価格

rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール 化学特性,用途語,生産方法

• 説明

  N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents. It is selective for NR2B subunit-containing receptors (IC₅₀ = 1 μM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits. Eliprodil also avidly binds σ₁ and σ₂ sites (K_is = 0.013 and 0.63 μM, respectively). It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion. Eliprodil can also have proarrhythmic actions in hearts under normal conditions.

• 使用

  Eliprodil is a noncardiac drug with neuroprotective properties. It is also a N-Methyl-D-aspartate receptor (NMDAR) antagonist.

• 生物活性

  Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC 50 values are 1, > 100 and > 100 μ M respectively). Also σ 1 ligand (K i = 0.013 μ M). Antagonizes neuronal voltage-gated Ca 2+ channels and selectively inhibits the rapid component of the delayed rectifier K + current (I Kr ). Neuroprotective.

rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール 生産企業

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rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール スペクトルデータ(¹HNMR)

119431-25-3, rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール キーワード