1-[4-[(6,7-ジメトキシ-4-キノリニル)オキシ]-2-メトキシフェニル]-3-[1-(2-チアゾリル)エチル]尿素

1-[4-[(6,7-ジメトキシ-4-キノリニル)オキシ]-2-メトキシフェニル]-3-[1-(2-チアゾリル)エチル]尿素 価格

1-[4-[(6,7-ジメトキシ-4-キノリニル)オキシ]-2-メトキシフェニル]-3-[1-(2-チアゾリル)エチル]尿素 化学特性,用途語,生産方法

• 説明

  Ki20227 is an inhibitor of macrophage colony stimulating factor 1 (CSF1) receptor tyrosine kinase (c-Fms; IC₅₀ = 2 nM). It inhibits CSF1-dependent c-Fms phosphorylation in a dose-dependent manner in RAW264.7 cells and reduces CSF1-dependent growth of M-NFS-60 cells (IC₅₀ = 14 nM). Ki20227 suppresses development of TRAP-positive osteoclast-like cells from murine bone marrow (IC₅₀ = 40 nM) and decreases the number and area of osteolytic lesions on femurs and tibiae in a murine A375 subcutaneous xenograft model. Ki20227 also reduces TNF-α infiltration and osteolytic bone destruction in a collagen-induced arthritis (CIA) mouse model.

• 使用

  Ki 20227 is a c-fms tyrosine kinase inhibitor, which suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.

1-[4-[(6,7-ジメトキシ-4-キノリニル)オキシ]-2-メトキシフェニル]-3-[1-(2-チアゾリル)エチル]尿素 生産企業

Global(110)Suppliers

1-[4-[(6,7-ジメトキシ-4-キノリニル)オキシ]-2-メトキシフェニル]-3-[1-(2-チアゾリル)エチル]尿素 スペクトルデータ(¹HNMR)

623142-96-1, 1-[4-[(6,7-ジメトキシ-4-キノリニル)オキシ]-2-メトキシフェニル]-3-[1-(2-チアゾリル)エチル]尿素 キーワード