[1R,(+)]-6,6',12'-トリメトキシ-2,2'-ジメチルオキシアカンタン-7-オール

[1R,(+)]-6,6',12'-トリメトキシ-2,2'-ジメチルオキシアカンタン-7-オール 化学特性,用途語,生産方法

• 説明

  A second bisbenzylisoquinoline base from Limacia cuspidata (Miers.) Hook. f. et Thorn., the alkaloid is separated from the accompanying !imacine by chromato? graphy on a silica column. It crystallizes in colourless prisms from MeOH-Me2 CO and has [α]_D + 110° (CHCI3). One hydroxyl group is present and the alkaloid yields the O-methyl ether as colourless needles, m.p. 210-2° C; [α]_D + 90°, (CHCI3), shown to be identical with N-methyl-dihydroepistephanine B. The structure has been established by chemical interconversions with limacine and cuspidaline (q.v.).

• 参考文献

  Tomita, Furukawa., Tetrahedron Lett., 4293 (I 966)
  Structure:
  Tomita, Furukawa, Fukagawa., l. Pharm. Soc., lapan, 87,793 (I967)

10172-03-9, [1R,(+)]-6,6',12'-トリメトキシ-2,2'-ジメチルオキシアカンタン-7-オール キーワード