カルボキシペプチダーゼB

カルボキシペプチダーゼB 化学特性,用途語,生産方法

• 性質

  Zn2+ 必須．活性基(ウシ)はGlu268とTyr246．C末端がArgまたはLysのとき加水分解で遊離

• 説明

  Carboxypeptidase B is an enzyme that specifically releases C-terminal lysine and arginine from substrates, and it was initially named "basic carboxypeptidase". It is distinguished from Anson's carboxypeptidase A and is also known as protaminase.

• 天然物の起源

  ヒト膵：111～417ウシ膵：306

• 特性

  Carboxypeptidase B catalyzes hydrolysis of the basic amino acids lysine, arginine and ornithine from the C-terminal end of polypeptides. The molecular weight is 34,500 daltons, the pH optimum is 7.9, and the pI is 6.0.

• 使用

  Carboxypeptidase B has been used for the mass spectroscopy analysis ofanti-K11/K48 bispecific antibody.

• 一般的な説明

  Peptidyl-L-lysine (-L-arginine) hydrolase. Carboxypeptidase B is secreted as a zymogen (pro-carboxypeptidase B) from the pancreas.

• Biochem/physiol Actions

  Carboxypeptidase B is a Zn2+-metalloprotease, which catalyzes the hydrolysis of the basic amino acids L-Lys and L-Arg from the C-terminal position in polypeptides.

カルボキシペプチダーゼB 生産企業

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