キモスタチン

キモスタチン 価格

キモスタチン 化学特性,用途語,生産方法

• 説明

  Chymostatin is a bioactive peptide of microbial origin that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases. It potently inhibits chymotrypsin and chymase (K_i = 9.36 and 13.1 nM, respectively) while less effectively blocking the activity of cathepsins, papain, and leukocyte elastase. It is without effect on trypsin, thrombin, plasmin, pepsin, and kallikrein.

• 使用

  Chymostatin is a specific inhibitor of α-, β-, γ-, and δ-chymotrypsin.

• 一般的な説明

  Chymostatin is a mixture of three components, A, B, and C. The component A being N-[((S)-1-carboxy-2-phenylethyl)-carbamoyl]-α-[2-iminohexahydro-4(S)-pyrimidyl]-L-glycyl-L-leucyl-phenylalaninal. The other two components B and C differ in that the L-leucyl residue is substituted by L-valine and L-isoleucine, respectively.

• 概要

  Streptomyces 属の産生するプロテアーゼ阻害剤．キモトリプシン，パパイン，カテプシン A, B を阻害．Leu →Val置換体 (MW 593.7)，Leu→Ile置換体 (MW 607.7)もある

キモスタチン 生産企業

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9076-44-2, キモスタチン キーワード