リザトリプタン安息香酸塩

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H360：生殖能または胎児への悪影響のおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

リザトリプタン安息香酸塩 価格

リザトリプタン安息香酸塩 化学特性,用途語,生産方法

• 外観

  白色～うすい褐色, 結晶性粉末～粉末又は塊

• 溶解性

  水及びメタノールにやや溶けやすく、エタノール(95)にやや溶けにくく、アセトニトリルに溶けにくく、ジエチルエーテルにきわめて溶けにくい。

• 用途

  5-HT1B 及び5-HT1D 受容体に 作用します。血管収縮作用及び血管拡張物質 抑制作用を示します。

• 効能

  抗片頭痛薬, 血管収縮薬, セロトニン受容体作動薬

• 商品名

  マクサルト (杏林製薬)

• 説明

  Rizatriptan was launched for the first time as Maxalt in Mexico for the acute treatment of migraine headaches with or without aura in adults. It is the third in a new generation of triptan migraine drugs to challenge the firstgeneration product Sumatriptan from Glaxo Wellcome, after Zolmitriptan (Zeneca) and Naratriptan (Glaxo Wellcome).
  It can be synthetically obtained by two related routes having respectively 3 and 4 steps, both starting from 1 -(4-aminobenzyl)-l,2,4-triazole. Rizatriptan is a full 5-HT1D/1B receptor agonist retaining a significant affinity at 5-HT1A sites (pIC50 = 6.4), with a low affinity for nond-HT sites. It shows craniovascufar selectivity for human isolated middle meningeal over coronary arteries ; its effect on coronary artery constriction is significantly less than that for Sumatriptan. Rizatriptan inhibits the release of neuropeptides that cause swelling of cranial blood vessels. Rizatriptan has a good oral bioavailability (64% and 47% in rats and dogs respectively). and a rapid onset of action : the headache relief in human occurs within 30 to 45 minutes of taking 20 mg. It also relieved nausea and hypersensitivity to noise (phonophobia) and light (photophobia) that are often symptoms accompanying a migraine attack. Among at least 6 metabolites identified in humans after a single oral dose (60 mg), the major urinary metabolite was the corresponding indole-3-acetic acid. Maxalt is available as a novel oral formulation of rapidly dissolving tablets or wafers that does not require liquid for ingestion.

• 化学的特性

  Off-White Solid

• 使用

  Rizatriptan Benzoate is a selective serotonin 5-HTID receptor agonist and used to treat migraine (1,2,3). It is structurally derived from tryptamine.

• 一般的な説明

  Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

リザトリプタン安息香酸塩 生産企業

Global(464)Suppliers

リザトリプタン安息香酸塩 スペクトルデータ(¹HNMR)

145202-66-0, リザトリプタン安息香酸塩 キーワード