(2R,3aβ,6aβ)-ヘキサヒドロ-N-メチル-2α,4α-メタノ-4H-フロ[3,2-b]ピロール-3α-アミン

(2R,3aβ,6aβ)-ヘキサヒドロ-N-メチル-2α,4α-メタノ-4H-フロ[3,2-b]ピロール-3α-アミン 化学特性,用途語,生産方法

• 説明

  This oily alkaloid has been obtained from a species of grass, Lotium cuneatum Nevski. It has a density of D ²⁰ 1.1343 and a refractive index of n²⁰_D 1.5505. It behaves as a diacidic base yielding a series of well crystalline salts and derivatives, e.g. the dihydrochloride, m.p. 256-7°C; [α]¹⁵_D + 6.2° (H20); dihydrobromide, m.p. 254-5°C (dec.); [α]²⁰_D + 3.5° (c 4.29, H20); dihydriodide, m.p. 233-5°C (dec.); [α]³⁴_D + 5.0° (c 13.2 H20); perchlorate, m.p. 282°C with almost explosive decomposition; sulphate, yellow needles, m.p. 250-2°C (dec.); mononitrate,m.p. 208-2l0°C; dinitrate, m.p. l48-9°C; [α]³⁸_D + 6.18° (c 6.94, H20); dipicrate, m.p. 258-260°C (dec.); methiodide, m.p. 2l0-loC and the N-nitroso derivative, m.p. 64°C. The N-acetyl derivative yields a crystalline hydrochloride, m.p. 197-8°C; [α]²⁰_D + 36.9° (H20) and the N-methyl compound is obtained as a colourless oil, b.p. 90-l oC/2 mm; [α]³¹_D+ 9.31° (c 9.5, MeOH). The alkaloid possesses an ether oxygen bridging the pyrrolizidine moiety.

• 危険性

  A poison.

• 参考文献

  Yunusov, Akramov., J. Gen. Chern., USSR, 25, 1765 (1955)
  Yunusov, Akramov., ibid, 30,699,705,3105 (1960)

(2R,3aβ,6aβ)-ヘキサヒドロ-N-メチル-2α,4α-メタノ-4H-フロ[3,2-b]ピロール-3α-アミン 生産企業

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