o-[3-(ヘキシルオキシ)-2-ヒドロキシプロポキシ]安息香酸

o-[3-(ヘキシルオキシ)-2-ヒドロキシプロポキシ]安息香酸 化学特性,用途語,生産方法

• Originator

  Droctil,Ciba Geigy,Italy,1971

• Manufacturing Process

  p-Hydroxy-benzoic acid methyl ester was subjected to a condensation reaction with 3-hexoxy-2-hydroxy-1-chloropropane in the presence of sodium ethylate and ethanol as a solvent, yielding p-(3-hexoxy-2-hydroxy)-propoxy-benzoic acid methyl ester.
  62 g of this intermediate product were admixed with 250 cc of 2N sodium hydroxide and the resulting mixture was refluxed for three hours. The reaction mixture was allowed to cool and was made acid with concentrated hydrochloric acid while cooling it on ice. An oil separated out which was extracted with ether. The ether extract solution was dried over sodium sulfate and then the ether was distilled off, leaving a crystalline mass as a residue. The crystalline product was recrystallized from a mixture of benzene and petroleum ether, yielding a compound having a MP of 68°C.

• Therapeutic Function

  Choleretic

o-[3-(ヘキシルオキシ)-2-ヒドロキシプロポキシ]安息香酸 上流と下流の製品情報

o-[3-(ヘキシルオキシ)-2-ヒドロキシプロポキシ]安息香酸 生産企業

Global(3)Suppliers

26281-69-6, o-[3-(ヘキシルオキシ)-2-ヒドロキシプロポキシ]安息香酸 キーワード