4-フェニル酪酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P405：施錠して保管すること。

4-フェニル酪酸 価格

MSDS Information

• 4-Phenylbutanoic acid

4-フェニル酪酸 化学特性,用途語,生産方法

• 外観

  白色～うすい褐色, 結晶～結晶性粉末又は塊

• 溶解性

  エタノール及びアセトンに溶けやすく、水に溶けにくい。アルコール、エーテルに易溶。

• 化学的特性

  4-Phenylbutyric acid is white to slightly yellowish crystalline powder. It is slightly soluble in chloroform and methanol. Its solubility in water is 5.3 g/l (at 40 °C).

• 製造方法

  4-phenylbutyric acid is obtained by the reaction of benzene with butyrolactone in the presence of aluminum chloride, followed by neutralization with base.
  Synthesis of 4-phenylbutyric acid

• 主な応用

  4-Phenylbutyric acid (4-PBA) is used in the treatment of urea cycle disorders under the trade name Buphenyl. 4-PBA has been used as a selective inhibitor of endoplasmic reticulum stress (ERS).
  4-Phenylbutyric acid is used as organic intermediates. It can also be used as a reactant in the synthesis of:
  1-Tetralone using Lewis acid catalyst.
  4,N-diphenylbutyramide.

• 定義

  4-Phenylbutyric acid is a monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apopto is in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.

• 一般的な説明

  4-Phenylbutyric acid (4-PBA) is a small-molecular-weight fatty acid with a terminal aromatic group, and its sodium salt (sodium 4-phenyl butyrate) has been used for the treatment of urea cycle disorders. This molecule is also used for the treatment of sickle cell diseases and thalassemia owing to its ability to activate β-globin transcription. Moreover, 4-PBA is employed as an orally bioavailable agent for the treatment of spinal muscular atrophy (SMA) and tumors.
  Neuroprotective Effects of 4-phenylbutyric Acid and Its Derivatives: Possible Therapeutics for Neurodegenerative Diseases

• 純化方法

  Crystallise the acid from pet ether (b 40-60o). [Beilstein 9 IV 1811.]

4-フェニル酪酸 上流と下流の製品情報

4-フェニル酪酸 生産企業

Global(467)Suppliers

4-フェニル酪酸 スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

1821-12-1, 4-フェニル酪酸 キーワード