(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
化学名:(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
CAS番号.1156491-10-9
英語名:(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
CBNumberCB22498775
MFC9H10ClF2N
MW205.63
MOL File1156491-10-9.mol
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride物理性質
| 融点 | >172°C (dec.) |
| 貯蔵温度 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解性 | DMSO（微量）、メタノール（微量） |
| 外見 | 個体 |
| 色 | 白い |
| InChI | InChI=1/C9H9F2N.ClH/c10-7-2-1-5(3-8(7)11)6-4-9(6)12;/h1-3,6,9H,4,12H2;1H/t6-,9+;/s3 |
| InChIKey | IMYLOCHFFLYHPS-RHUSADAZNA-N |
| SMILES | N[C@@H]1C[C@H]1C1C=CC(F)=C(F)C=1.Cl |&1:1,3,r| |
1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to
produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by
addition of N,N-dimethylformamide,
phloroglucinol and sodium iodide in the next step converted to
1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the
latter intermediate is in the subsequent step stereochemically reduced
to hydroxyl group by the use of chiral oxazaborolidine together with
borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol
is then added to a mixture of triphenylphosphine and
diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust.