テトロドトキシンくえん酸塩
化学名:テトロドトキシンくえん酸塩
CAS番号.18660-81-6
英語名:TETRODOTOXIN CITRATE
CBNumberCB2192024
MFC17H25N3O15
MW511.39
MOL File18660-81-6.mol
别名
テトロドトキシンくえん酸塩
TTX・くえん酸塩
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テトロドトキシンくえん酸塩物理性質
| 貯蔵温度 | Desiccate at -20°C |
| 溶解性 | Citrate Buffer (pH 4.8): 30 mg/ml (100 mM) |
| 外見 | A solid |
| 酸解離定数(Pka) | 8.76(at 25℃) |
| 水溶解度 | Soluble to 100 mM in water |
| 安定性： | Unstable in Acidic solution, Unstable In Acidic Solution |
| 主な危険性 | T+ |
| Rフレーズ | 26/27/28 |
| Sフレーズ | 22-36/37/39-45 |
| RTECS 番号 | IO1450000 |
| 毒性 | A toxin contained in the ovary and liver of puffer fish, in the eggs of the California newt and in some other animals. It is used as a chemical tool for the study of ion channels. The s.c. LD50 in mice is 10 mg/kg. It is a toxicant of nerve and muscle by blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and hypotension. There is no antidote. Therapy involves artificial respiration. |
