N-(6-アミノヘキシル)-5-クロロ-1-ナフタレンスルホンアミド塩酸塩

N-(6-アミノヘキシル)-5-クロロ-1-ナフタレンスルホンアミド塩酸塩 価格

N-(6-アミノヘキシル)-5-クロロ-1-ナフタレンスルホンアミド塩酸塩 化学特性,用途語,生産方法

• 外観

  白色～わずかにうすい褐色, 結晶性粉末～粉末

• 溶解性

  メタノール及び水に溶け、アセトンに溶けない。

• 説明

  Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (K_i = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (K_i = 70 and 300 μM, respectively).

• 化学的特性

  White Crystalline Solid

• 使用

  W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.

• 一般的な説明

  A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 μM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 μM).

• 生物活性

  Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).

N-(6-アミノヘキシル)-5-クロロ-1-ナフタレンスルホンアミド塩酸塩 生産企業

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N-(6-アミノヘキシル)-5-クロロ-1-ナフタレンスルホンアミド塩酸塩 スペクトルデータ(¹HNMR、IR、Raman)

61714-27-0, N-(6-アミノヘキシル)-5-クロロ-1-ナフタレンスルホンアミド塩酸塩 キーワード