3-ブロモ-2-ナフトール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H315：皮膚刺激

  H318：重篤な眼の損傷

  H335：呼吸器への刺激のおそれ

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

3-ブロモ-2-ナフトール 価格

3-ブロモ-2-ナフトール 化学特性,用途語,生産方法

• 外観

  白色～うすい黄色粉末～結晶

• 合成

  3-Bromo-2-naphthol is synthesised using 2-bromo-3-methoxynaphthalene as a raw material by chemical reaction. The specific synthesis steps are as follows:
  General procedure: To a Schlenk flask were added 2-bromo-3-methoxynaphthalene(1.0 equiv), aryl boronic acid (2.2 equiv), K₂CO₃ (3.0 equiv), Pd(PPh3)4 (2.5 mol%), and degassed EtOH/toluene/water (1/1/1) under Ar atmosphere. The mixture was heated at 90 °C until thecompletion of the reaction. Then the mixture was cooled to room temperature, and DCM was added. The mixture was washed with NaOH solution (20% wt), and the aqueous phase was extracted with DCM (2 × 20 mL). The combined organic phase was washed with brine (20 mL) and dried overanhydrous MgSO₄. After removing the solvent, the residue was dissolved in anhydrous DCM. Thesolution was cooled to -78 °C, and BBr3 (1 M in DCM, 5.0 equiv) was added slowly by syringe. Thenthe mixture was warmed up to room temperature and stirred until the complete consumption of thestarting material. The mixture was poured into the ice water (50 mL) and extracted with DCM (3 × 50mL). The combined organic phase was washed with brine (100 mL) and dried over anhydrous Na₂SO4. After removing the solvent, the residue was purified by silica gel chromatography to give 3-Bromo-2-naphthol.
  
  

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3-ブロモ-2-ナフトール スペクトルデータ(¹HNMR、IR1、IR2、MS)

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