デオキシノジリマイシン塩酸塩

デオキシノジリマイシン塩酸塩 価格

デオキシノジリマイシン塩酸塩 化学特性,用途語,生産方法

• 効能

  薬理学的シャペロン (α-グルコシダーゼ)

• 説明

  1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities. It inhibits the activities of α- and β-glucosidase (IC₅₀s = 35 and 71 μM, respectively). 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells. It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM. 1-DNJ (1-100 μg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells. It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.

• 化学的特性

  White Crystalline Solid

• 一般的な説明

  Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc₃Man₉GlcNAc₂ in N-linked glycan biosynthesis.

デオキシノジリマイシン塩酸塩 生産企業

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