フェンカンファミン

フェンカンファミン 化学特性,用途語,生産方法

• 効能

  中枢神経刺激薬

• Originator

  Fencamfamin,Shanghai Lansheng

• Manufacturing Process

  1) 28.05 g of 2-phenyl-3-aminobicyclo[2.2.1]heptane are mixed with 6.9 g acetaldehyde keeping the mixture cool. The mixture is heated for 20 minutes on the stream bath under reflux, and the reaction product is freed from water in vacuum at 60°C. The crude base is dissolved in 300 ml of methanol and hydrogenated with 2 previously reduced platinum oxide. After it has taken up the calculated quantity of hydrogen, the solvent is distilled off in vacuum, the residue dissolved in dilute hydrochloric acid and the neutral by-products are shaken out with ether. The aqueous solution is made alkaline with caustic soda and extracted with ether. From ethereal solution 13.2 g of the base are obtained with a boiling point at 1 mm of 128°-131°C.
  25 g of 2-phenyl-3-aminobicyclo[2.2.1]heptane,15 g Raney nickel and 75 ml absolute alcohol are boiled under a reflux for 15 hours. The filtrate from the catalyst is neutralised with dilute hydrochloric acid and distilled to dryness in vacuum. The hydrochloric residue is purified by recrystallisation from acetone or dioxane-petrol-ether. Yield 21.5 g; MP: 191°C.

• Therapeutic Function

  Central stimulant, Anorexic

フェンカンファミン 上流と下流の製品情報

1209-98-9, フェンカンファミン キーワード