2-[5-(4-アミノフェノキシ)ペンチル]-1H-イソインドール-1,3(2H)-ジオン

2-[5-(4-アミノフェノキシ)ペンチル]-1H-イソインドール-1,3(2H)-ジオン 化学特性,用途語,生産方法

• Originator

  Amphotalide,ZYF Pharm Chemical

• Manufacturing Process

  A mixture of 5-phthalimidopentyl bromide (Drake and Garman, J.Amer. Chem. Sec, 1949, 71, 2426) (296.0 g) and potassium p-nitrophenoxide (177.0 g) in ethanol (1.5 L) was stirred mechanically, boiled under reflux for 20 h, concentrated to half its volume, cooled and filtered. The product was washed with water, dried and crystallised from acetone, giving 1-p-nitrophenoxy-5- phthalimidopentane, melting point 123°-124°C.
  The foregoing 1-p-nitrophenoxy-5-phthalimidopentane (100.0 g) in ethanol (1 L) was reduced by hydrogen over 2% of platinum oxide at 74°C/73 lb. per sq. in. The filtered solution on cooling gave L-p-aminophenoxy-5-phthalimidopentane, melting point 111°-112° C (recrystallisation from ethanol).

• Therapeutic Function

  Antischistosomal

2-[5-(4-アミノフェノキシ)ペンチル]-1H-イソインドール-1,3(2H)-ジオン 上流と下流の製品情報

2-[5-(4-アミノフェノキシ)ペンチル]-1H-イソインドール-1,3(2H)-ジオン 生産企業

Global(6)Suppliers

1673-06-9, 2-[5-(4-アミノフェノキシ)ペンチル]-1H-イソインドール-1,3(2H)-ジオン キーワード