CYCLIC AMP 化学構造式

CYCLIC AMP

化学名:CYCLIC AMP

CAS番号.86594-35-6

英語名:CYCLIC AMP

CBNumberCB1747869

MFC10H12N5O6P

MW329.21

MOL File86594-35-6.mol

CYCLIC AMP物理性質

融点	260 °C (dec.)(lit.)
貯蔵温度	2-8°C
溶解性	H2O: 10 mg/mL 水溶液の pH は約 3.0 です。そのナトリウム塩はより溶けやすいです。無色透明
外見	粉
色	白い
安定性：	吸湿性

安全性情報

主な危険性	C
Rフレーズ	34
Sフレーズ	22-24/25
WGK Germany	3
RTECS 番号	AU7357600
F	10-21

CYCLIC AMP 化学特性,用途語,生産方法

酵素阻害剤
This prototypical second messenger (FWfree-acid = 329.21 g/mol; lmax = 259 nm; eM = 15400 M–1cm–1; Abbreviation: 3’,5’-cyclic AMP, 3’,5’-cAMP, opr cAMP), the isolation of which in the late 1950s earned Earl Sutherland his share of the 1971 Nobel Prize in Medicine & Physiology, activates susceptible protein kinases in signal transduction cascades. Elevated cAMP concentrations also activate cyclicAMP-gated ion channels; Exchange Proteins Activated by cAMP (or EPAC), such as RAPGEF3; and popeye domain-containing proteins (or Popdc). While many enzymes are weakly inhibited by cAMP (with inhibition constants typically in the 0.1 mM range or above), the peak physiologic concentration of cAMP rarely exceeds 1020 μM. Target(s): phosphate-activated glutaminase; glyceraldehyde3-phosphate dehydrogenase, Ki = 0.11 mM for the yeast enzyme; choline kinase; Bacillus subtilis ribonuclease; NAD(P)+ transhydrogenase, AB-specific; phosphofructokinase, weakly inhibited; hexokinase; adenosine deaminase; NAD+ nucleosidase, or NADase; poly(ADP-ribose) glycohydrolase; GMP synthetase; 5-phosphoribosylamine synthetase, or ribose-5phosphate:ammonia ligase; tyrosyl-tRNA synthetase, weakly inhibited; adenylylsulfatase; CDP-diacylglycerol diphosphatase; nucleotide diphosphatase, weakly inhibited; ATP diphosphatase, slight inhibition; keratan sulfotransferase, weakly inhibited; adenosylhomocysteinase; 6-phospho-b-glucosidase; prenyldiphosphatase; CMP-N-acylneuraminate phosphodiesterase; 2’,3’-cyclic-nucleotide 3’-phosphodiesterase, or cCMP phosphodiesterase; 3’,5’-cyclic-GMP phospho-diesterase, or cGMP phosphodiesterase; sphingomyelin phosphodiesterase; phosphoprotein phosphatase; 5’-nucleotidase; acid phosphatase; diacylglycerol cholinephosphotransferase; ethanolaminephosphotransferase; glucose-1-phosphate adenylyltransferase; nucleoside diphosphate kinase; AMP:thymidine kinase; diacylglycerol kinase; nucleoside phosphotransferase; 1phosphatidylinositol 4-kinase; NAD+ kinase (63; procollagen glucosyltransferase64; chitin synthase, weakly inhibited; glycogen phosphorylase, weakly inhibited; luciferase, firefly (Photinus-luciferin 4-monooxygenase, ATP-hydrolyzing.

CYCLIC AMP 生産企業

86594-35-6, CYCLIC AMP キーワード

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