RO-31-7549

RO-31-7549 化学特性,用途語,生産方法

• 使用

  It is a potent inhibitor of protein kinase C (PKC) activity.

• 一般的な説明

  A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC₅₀ = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ₁. Exhibits some degree of PKC isozyme specificity (IC₅₀ = 53 nM for PKC_α, 195 nM for PKC_βI, 163 nM for PKC_βII, 213 nM for PKC_γ, and 175 nM for PKC_ε). Inhibits carbachol-evoked noradrenaline release (IC₅₀ = 600 nM).

• Biochem/physiol Actions

  Cell permeable: yes

RO-31-7549 生産企業

Global(39)Suppliers

125313-65-7, RO-31-7549 キーワード