2-クロロ-4-[[(1R,2S)-1-[5-(4-シアノフェニル)-1,3,4-オキサジアゾール-2-イル]-2-ヒドロキシプロピル]アミノ]-3-メチルベンゾニトリル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

  P330：口をすすぐこと。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

  P403+P233：換気の良い場所で保管すること。容器を密閉 しておくこと。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

2-クロロ-4-[[(1R,2S)-1-[5-(4-シアノフェニル)-1,3,4-オキサジアゾール-2-イル]-2-ヒドロキシプロピル]アミノ]-3-メチルベンゾニトリル 化学特性,用途語,生産方法

• 説明

  RAD140 (also known as Testolone) is an oral nonsteroidal selective androgen receptor modulator (SARM) that cannot be converted to estrogen by aromatase. It has been demonstrated that RAD140 has high AR affinity and target selectivity, showing marked tissue-selective AR agonist activity comparable to natural androgens in breast cancer cells, while lacking agonist activity in prostate cancer cells.
  We have recently reported anti-tumor activity of RAD140 in multiple in vivo and in vitro models of AR/ER+ breast cancer as a single agent and in combination with inhibitors of CDK4/6 and mTOR.
  Pharmacodynamic investigation indicates RAD140 acted as an AR agonist in breast cancer cells while suppressing ER signaling and reduced ESR1 mRNA expression.
  
  RAD140 exhibited anti-tumor activity in patient-derived xenograft (PDX) models of AR/ER+ breast cancer, as single agent and in combination with inhibitors of CDK4/6 or mTOR
  RAD140 inhibited ER signaling and ESR1 mRNA level in the HBCx-22 PDX model.

• 使用

  RAD140 is a potent, orally bio-available, and non-steroidal selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.

• 利点

  Significant and selective anabolic effect on muscles and bones, without strong androgenic adverse effects on other organs
  Has strong neuroprotective effects, may be effective in preventing Alzheimer’s disease and related neurodegenerative disorders
  Has the potential to fight breast cancer
  Can help treat serious diseases associated with muscle loss
  Can help protect brain cells and their proper functions
  May help in the treatment of osteoporosis
  Helps build and maintain muscle mass
  May help reduce excess fat

• 生物活性

  RAD140 is an orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM) that binds to the androgen receptor with a Ki value of 7nM. At 0.03-0.3mg/kg, it has been shown to stimulate muscle weight increase without affecting prostate or seminal vesicle in castrated male rats. At 0.3-1 mg/kg, RAD140 demonstrates partial antagonist activity in seminal vesicle and prostate.

• 副作用

  In animal studies, RAD 140 has shown to be safer than testosterone replacement therapy, when administered to rats. This is impressive, given the general positive safety profile of testosterone, hence its FDA-approved status.
  However, in humans there appears to be a different trend, with RAD 140 demonstrating harsher side effects.
  Suppressed levels of natural Testosterone
  Anxiety, depression
  Nausea and vomiting
  Possible liver toxicity
  Abnormal body hair growth in women
  Excessive hair loss in men (which stops after the end of RAD140 treatment)
  The long-term effects of RAD140 are unknown

2-クロロ-4-[[(1R,2S)-1-[5-(4-シアノフェニル)-1,3,4-オキサジアゾール-2-イル]-2-ヒドロキシプロピル]アミノ]-3-メチルベンゾニトリル 上流と下流の製品情報

2-クロロ-4-[[(1R,2S)-1-[5-(4-シアノフェニル)-1,3,4-オキサジアゾール-2-イル]-2-ヒドロキシプロピル]アミノ]-3-メチルベンゾニトリル 生産企業

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