パラドフロキサシン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H341：遺伝性疾患のおそれの疑い

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P281：指定された個人用保護具を使用すること。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

  P330：口をすすぐこと。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

パラドフロキサシン 化学特性,用途語,生産方法

• 使用

  Pradofloxacin is a novel fluoroquinolone antibiotic. An antimicrobial agent.

• 適応症

  Dogs: Pradofloxacin is a novel third-generation fluoroquinolone currently approved in Europe to treat canine wound infections and superficial and deep pyoderma associated with susceptible strains of Staphylococcus pseudinterme- dius. However, it has shown lower minimal inhibitory concentration (MIC) when compared to various fluoroquinolones for the following organisms: Bordetella, Escherichia coli, Enterococcus, Klebsiella pneumonia, Staphylococcus, Staphy- lococcus pseudintermedius, Streptococcus, Pseudomonas, Proteus, Mycoplasma, Salmonella, and Pasteurella. Moreover, in contrast to other fluoroquinolones, pradofloxacin has shown excellent in-vitro activity against anaerobic bacteria isolated from dogs and cats. Pradofloxacin, concurrently with topical therapy, may also be of benefit for treatment of chronic ear infections, particularly otitis media, caused by susceptible organisms such as Pseudomonas. However, tissue concentration is not known for the external or middle ear, and this indication is controversial with unpredictable efficacy.
  Note: The authors do not recommend the use of fluoroquinolones as first-line therapy for pyoderma. Fluoroquinolones should be considered primarily for chronic deep pyodermas associated with extensive scar tissue, because of their excellent tissue penetration. Antibiotic selection, however, should be based on culture and susceptibility results.

• 作用機序

  Pradofloxacin is a third-generation fluoroquinolone that inhibits DNA supercoiling and synthesis by inhibition of bacterial DNA gyrase and topoisomerase IV. Because of these two fluoroquinolone targets, development of resistance is less likely than with other fluoroquinolones. Similarly to other fluoroquinolones, pradofloxacin accumulates inside inflammatory cells, in particular in macrophages.

• 副作用

  Dogs: pradofloxacin is generally well tolerated, but it may cause nausea, vomiting, diarrhea, soft stools, lethargy. These signs are typically mild and transient. It can induce seizure when administered at high doses.

• 薬物相互作用

  Antacids containing divalent or trivalent cations (e.g., Mg++, Al++, Ca++), iron, zinc: decrease pradofloxacin absorption; separate administration of these products and pradofloxacin by at least 2 hours
  Aminoglycosides, third-generation cephalosporins, extended spectrum penicillins: drug synergism may occur, especially against Pseudomonas
  Digoxin: may increase oral bioavailability of digoxin Cyclosporine: may reduce the metabolism of cyclosporine
  Methotrexate, theophylline: may increase the blood levels of these drugs
  Nitrofurantoin: may reduce the antimicrobial effect of fluoroquinolones

パラドフロキサシン 生産企業

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