Milbemycin oxime

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P273：環境への放出を避けること。

  P391：漏出物を回収すること。

  P501：内容物/容器を．．．に廃棄すること。

Milbemycin oxime 価格

Milbemycin oxime 化学特性,用途語,生産方法

• 使用

  Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of two natural products, milbemycin A3 and A4 (in ~30:70 ratio). Milbemycin oxime is used therapeutically for the prevention of intestinal parasites in dogs. Like the other milbemycin/avermectins, it was developed for intestinal parasite control in animals and acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.

• 臨床応用

  Milbemycin oxime (Milbemycin) is available as an oral chewable tablet (2.3–27 mg) for heartworm prevention in dogs and cats, as well as a 0.1% otic solution for treating ear mites. It is not available in a more concentrated dosage form, so overdoses are relatively rare[1].

• Veterinary Drugs and Treatments

  Milbemycin tablets are labeled as a once-a-month heartworm preventative (Dirofilaria immitis) and for hookworm control (Ancylostoma caninum). It has activity against a variety of other parasites, including adult hookworms (A. caninum), adult roundworms (T. canis, T. leonina) and whipworms (Trichuris vulpis). In cats, milbemycin has been used successfully to prevent larval infection of Dirofilaria immitis.
  Milbemycin, like ivermectin can be used for treatment of generalized demodicosis in dogs, but treatment can be significantly more expensive. It is likely safer to use in breeds susceptible to mdr1 genetic mutation (Collies, Shelties, Australian shepherds, etc.) at the doses used for this indication, but neuro toxicity is possible. Older dogs, those that have had a long duration of disease prior to treatment, and dogs with pododemodicosis appear have a lower success rate with milbemycin treatment.

Milbemycin oxime 上流と下流の製品情報

Milbemycin oxime 生産企業

Global(280)Suppliers

Milbemycin oxime スペクトルデータ(¹HNMR)

129496-10-2, Milbemycin oxime キーワード