(±)-ブレビスタチン

化学名:(±)-ブレビスタチン

CAS番号.674289-55-5

英語名:(+/-)-BLEBBISTATIN

CBNumberCB0787697

MFC18H16N2O2

MW292.33

MOL File674289-55-5.mol

别名

(±)-ブレビスタチン

1-フェニル-3a-ヒドロキシ-6-メチル-2,3-ジヒドロ-1H-ピロロ[2,3-b]キノリン-4(3aH)-オン

3a-ヒドロキシ-6-メチル-1-フェニル-1H,2H,3H,3aH,4H-ピロロ[2,3-b]キノリン-4-オン

(±)-ブレビスタチン物理性質

融点	210-212°C
沸点	507.3±60.0 °C(Predicted)
比重(密度)	1.31±0.1 g/cm3(Predicted)
貯蔵温度	−20°C
溶解性	クロロホルム（微量）、ジクロロメタン、DMSO、酢酸エチル、メタノール
酸解離定数(Pka)	11.15±0.20(Predicted)
外見	明るい黄色の固体。
色	黄色
InChI	InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3
InChIKey	LZAXPYOBKSJSEX-UHFFFAOYSA-N
SMILES	N1C2=C(C=C(C)C=C2)C(=O)C2(O)CCN(C3=CC=CC=C3)C=12
CAS データベース	674289-55-5

安全性情報

主な危険性	Xn
Rフレーズ	20/21/22-36/37/38
Sフレーズ	26-36/37
WGK Germany	WGK 2
ストレージクラス	11 - Combustible Solids

危険有害性情報のコード(GHS)

(±)-ブレビスタチン価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01TRCB592490	5mg	￥31500	(±)-ブレビスタチン	購入
富士フイルム和光純薬株式会社(wako) W01TOC1760	10mg	￥110000		購入
富士フイルム和光純薬株式会社(wako) W01TRCB592490	10mg	￥44100	(±)-ブレビスタチン	購入
富士フイルム和光純薬株式会社(wako) W01TRCB592490	25mg	￥99600	(±)-ブレビスタチン	購入
富士フイルム和光純薬株式会社(wako) W01TRCB592490	50mg	￥163400	(±)-ブレビスタチン	購入

(±)-ブレビスタチン化学特性,用途語,生産方法

説明
(±)-Blebbistatin is a racemic mixture of (–)-blebbistatin and (+)-blebbistatin , the active and inactive forms, respectively. (–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC₅₀ = 8 μM). Through these effects, (–)-blebbistatin blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin are more stable forms of (–)-blebbistatin and (+)-blebbistatin, respectively. The addition of a nitro group stabilizes the molecules to circumvent their degradation by prolonged blue light exposure. (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin have the same stereochemistry of the active and inactive enantiomers, respectively.
化学的特性
Bright Yellow Solid
使用
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. (±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
定義
ChEBI: A pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase ac ivity of non-muscle myosin II.
生物活性
Selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

(±)-ブレビスタチン生産企業

(±)-ブレビスタチンスペクトルデータ(¹HNMR)

674289-55-5, (±)-ブレビスタチンキーワード

Send Inquriy

(±)-ブレビスタチン

危険有害性情報のコード(GHS)

(±)-ブレビスタチン 価格

(±)-ブレビスタチン 化学特性,用途語,生産方法

(±)-ブレビスタチン 生産企業

(±)-ブレビスタチン スペクトルデータ(1HNMR)

674289-55-5, (±)-ブレビスタチン キーワード

(±)-ブレビスタチン価格

(±)-ブレビスタチン化学特性,用途語,生産方法

(±)-ブレビスタチン生産企業

(±)-ブレビスタチンスペクトルデータ(¹HNMR)

674289-55-5, (±)-ブレビスタチンキーワード