Lipopolysaccharides, abbreviated as LPS, are large glycolipid molecules. They consist of three structural domains: Lipid A, the core oligosaccharide and the O-antigen. Lipid A is the hydrophobic portion of the molecule; it is an acetylated β-1'-6-linked glucosamine disaccharide that forms the outer leaflet of the outer membrane. Mature Lipid A is predominantly hexacylated. The core oligosaccharide is a non-repeating oligosaccharide segment linked to the glucosamine in Lipid A. Its core structure typically comprises 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo), a heptosaccharide and various hexosaccharides; these sugars may be modified by phosphate groups and other substituents (such as phosphoethanolamine). The O-antigen is an extended polysaccharide segment attached to the core oligosaccharide, consisting of repeating oligosaccharide chains comprising two to eight sugars [1].
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Lipopolysaccharides (LPS) exhibit strong amphiphilic properties. The acyl chains of Lipid A confer hydrophobic properties, whilst the core oligosaccharides and O-antigen confer hydrophilic properties, resulting in a unique asymmetric bilayer structure. Research indicates that this substance possesses structural barrier functions, immunomodulatory functions, and anti-complement and anti-phagocytic effects [1]. It protects the outer cell wall of Gram-negative bacteria and acts as a potent inducer of the human immune system.
